The incidence of intellectual disability is 1-3% in the human population (NIH/NLM) and the number of autistic individuals is on the rise. A shared pathology in human and mouse models of intellectual disability, neurodegenerative diseases, and other neurological disorders is abnormal cerebral cortical organization and neuronal morphology. The research in Dr. Redmond’s lab examines the roles of proteins and genes in the development and maturation of the cerebral cortex. The role of signaling proteins, such as CaMKIIβ, that translate neuronal activity into changes in neuronal shape and connections is the focus of Dr. Redmond’s research. Genetically modified mice, immunohistochemical, biochemical, and molecular biological approaches are used to elucidate the role of signaling proteins in the development of the central nervous system and differentiation of neurons.