Search results

• 2023

  Cardioprotective effects of naltrindole in rat myocardial ischemia/reperfusion injury are concentration-dependent

  Clair, L., Boakye, T., Ramsarran, J., Talukder, Z., Maricic, N., Kalu, U., Melnik, J., Dean, T., Chen, Q., Barsotti, R. J. & Young, L. H., May 3 2023.

  Research output: Contribution to conference › Presentation

  Open Access

  File

• Comparison of the inhibition of an OCT3 transporter inhibitor, Nilotinib, on Doxorubicin’s effects on cardiac and cancer cell lines

  Tan, Z. G., Melnik, J., Belsare, A., Huang, J., Lyons, M., Dowes, K., Kaur, G., Young, L. H., Barsotti, R. J. & Chen, Q., May 3 2023.

  Research output: Contribution to conference › Presentation

  Open Access

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• Dual myristic acid and trans-activator of transcription conjugation of PKC Beta II peptide inhibitor augments cellular delivery to counteract myocardial ischemia/reperfusion injury

  Ramsarran, J., Clair, L., Augustin, T., Talukder, Z., Andrews, E., Dean, T., Chen, Q., Barsotti, R. J. & Young, L. H., May 3 2023.

  Research output: Contribution to conference › Presentation

  Open Access

• In vitro naltrindole mitigates phorbol 12-myristate 13-acetate induced superoxide release in polymorphonuclear leukocytes independent of delta opioid receptor antagonism

  Johnson, D. A., DiLisi, T. A., Melnik, J., Pinto, D., Barrera, A., Nair, A., Talukder, Z., Dean, T., Chen, Q., Barsotti, R. J. & Young, L. H., May 3 2023.

  Research output: Contribution to conference › Presentation

  Open Access

• Myristoylated Protein Kinase C Epsilon Peptide Inhibitor (Myr-PKC ε-) mitigates renal ischemia-reperfusion injury and PKCε translocation to epithelial cell membranes in vivo

  Talukder, Z., Singh, S. G., Verwoert, A. B., Dean, T. C., Johnson, D., Shah, L., Sleeper, S., Melnik, J., Chen, Q., Barsotti, R. J., Jiang, Y., George, J., Agarwal, A. & Young, L. H., May 3 2023.

  Research output: Contribution to conference › Presentation

  Open Access

• Pretreatment with Naltrindole Generates Dose Dependent Effects on Reduction of Infarct Size During Myocardial Ischemia Reperfusion in An In-Vivo Model

  Humayun, A., Singh, S., Gray, A., Johnson, D., Dean, T., Chen, Q., Barsotti, R. J., Young, L. H., Dai, W. & Kloner, R., May 3 2023.

  Research output: Contribution to conference › Presentation

  Open Access

• Protein Kinase C Beta II Inhibitor combined with Conjugated Myristic Acid and Trans-Activator of Transcription achieves cardiovascular protection in porcine myocardial ischemia/reperfusion model

  Melnik, J. M., Harrell, K., Nair, A., Tanoh, D. B., Singh, S. G., Andrews, E., Dean, T. C., Chen, Q., Barsotti, R. J. & Young, L. H., May 3 2023.

  Research output: Contribution to conference › Presentation

  Open Access

• The effects of Mitoquinone on simulated ischemia/reperfusion injuries in H9c2 cells

  Ott, B., Melnik, J., Lyons, M., Dowes, K., Kaur, G., Young, L. H., Barsotti, R. J. & Chen, Q., May 3 2023.

  Research output: Contribution to conference › Presentation

  Open Access

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• The effects of mitoquinone pretreatment on doxorubicin-induced acute cardiac dysfunction

  Dawes, K., Melnik, J., Lyons, M., Amora, J., Young, L. H., Barsotti, R. J. & Chen, Q., May 3 2023.

  Research output: Contribution to conference › Presentation

  Open Access

  File
• 2022

  Dual conjugation of protein kinase C epsilon peptide inhibitor with myristic acid and trans-activator of transcription mitigates myocardial ischemia-reperfusion injury in an in vivo porcine model

  Singh, S., Dean, T. C., Boakye Tanoh, D., Harrell, K., Nair, A., Stinson, C., Humayun, A., Chen, Q., Barsotti, R. J. & Young, L. H., May 11 2022.

  Research output: Contribution to conference › Presentation

• Infarct-sparing effects of naltrindole and analogues through inhibition of myocardial hypercontracture during ischemia/reperfusion injury

  Boakye Tanoh, D., Clair, L., Taylor, T., Singh, S., Stinson, C., Nair, A., Johnson, D., Harrell, K., Humayun, A., Dean, T., Chen, Q., Barsotti, R. J. & Young, L. H., May 11 2022.

  Research output: Contribution to conference › Presentation

• Intracellular Delivery of Protein Kinase C Beta II Peptide Inhibitor is Facilitated by Dual Conjugation with Myristic Acid and Trans Activator of Transcription to Attenuate Myocardial Ischemia/Reperfusion Injury

  Clair, L., Ramsarran, J., Augustin, T., Stinson, C., Dean, T., Chen, Q., Barsotti, R. J. & Young, L. H., May 11 2022.

  Research output: Contribution to conference › Presentation

• Myristic Acid-Trans-Activator of Transcription Dual Conjugation Enhances Intracellular delivery of protein kinase C beta II peptide inhibitor for concentration-dependent attenuation of superoxide release in isolated rat polymorphonuclear leukocytes

  Verwoert, A. B., Singh, S. G., Nair, A., Johnson, D., Humayun, A., Clair, L., DiLisi, T., Harrell, K., Dean, T., Chen, Q., Barsotti, R. J. & Young, L. H., May 11 2022.

  Research output: Contribution to conference › Presentation

• Myristic Acid-Trans-Activator of Transcription Dual Conjugation Improves Intracellular Delivery of Protein Kinase C Beta II Peptide Inhibitor Cargo in Isolated Rat Polymorphonuclear Leukocytes

  Singh, S. G., Verwoert, A., Nair, A., Johnson, D., Humayun, A., Clair, L., DiLisi, T., Harrell, K., Dean, T., Chen, Q., Barsotti, R. J. & Young, L. H., Apr 2022.

  Research output: Contribution to conference › Presentation

• Myristoylated Protein Kinase C Beta II Inhibitor Attenuates Renal Injury in Mice Subjected to Severe Bilateral Ischemia-Reperfusion

  Shah, L., Johnson, D., Verwoert, A. B., Singh, S. G., Dean, T. C., Chen, Q., Barsotti, R. J. & Young, L. H., Apr 2022.

  Research output: Contribution to conference › Presentation

• Myristoylated Protein Kinase C Beta II Inhibitor Attenuates Severe Acute Kidney Injury Induced by Ischemia-Reperfusion

  Sleeper, S., Shah, L., Johnson, D., Verwoert, A. B., Singh, S. G., Dean, T. C., Chen, Q., Barsotti, R. J., Jiang, Y., George, J., Agarwal, A. & Young, L. H., May 3 2022.

  Research output: Contribution to conference › Presentation

• Naltrindole Pretreatment Exhibits Robust Cardioprotection in an Acute In Vivo Model of Ischemia/Reperfusion

  Humayun, A., Singh, S. G., Gray, A., Johnson, D., Nair, A., Stinson, C., Dean, T., Chen, Q., Barsotti, R. J. & Young, L. H., Apr 2022.

  Research output: Contribution to conference › Presentation

• Preconditioning Using Naltrindole or its Analogues Exerts Robust Infarct-Sparing Effects in Rat Myocardial Ischemia/Reperfusion

  Boakye Tano, D., Clair, L., Taylor, T., Singh, S., Stinson, C., Nair, A., Johnson, D., Harrell, K., Humayun, A., Dean, T., Chen, Q., Barsotti, R. J. & Young, L. H., Apr 2022.

  Research output: Contribution to conference › Presentation

• Pretreatment with Naltrindole Demonstrates Cardioprotection in an Acute In Vivo Model of Ischemia/Reperfusion Injury

  Humayun, A., Singh, S., Gray, A., Johnson, D., Nair, A., Stinson, C., Dean, T., Chen, Q., Barsotti, R. J., Young, L. H., Dai, W. & Kloner, R., May 11 2022.

  Research output: Contribution to conference › Presentation

• Renal function in a mouse model of acute kidney injury is improved by myristoylated protein kinase c epsilon inhibitor

  Verwoert, A. B., Singh, S. G., Dean, T. C., Johnson, D., Shah, L., Chen, Q., Barsotti, R. J., Jiang, Y., George, J., Agarwal, A. & Young, L. H., May 11 2022.

  Research output: Contribution to conference › Presentation

• The effects of ascorbic acid and sodium ascorbate on doxorubicin-induced H9c2 cell damage

  Ghofrani, S., Mercado, K. A., Malik, N., Dawes, K., Barsotti, R., Young, L. & Chen, Q., May 11 2022.

  Research output: Contribution to conference › Presentation

• 2021

  Investigating the potential cardioprotective properties of two novel microbiome derived compounds urolithin a and urolithin b against methylglyoxal induced cellular damage

  Yasin, A. & Chen, Q., May 10 2021.

  Research output: Contribution to conference › Presentation

  Open Access

  File

• Pretreatment with Naltrindole exhibits robust cardioprotection in an isolated rat heart model of ischemia-reperfusion injury

  Verwoert, A., Nair, A., Bamimore, M., Dean, T., Singh, S., Beale, M., Harrell, K., Stinson, C., Chen, Q., Barsotti, R. J. & Young, L. H., May 10 2021.

  Research output: Contribution to conference › Presentation

  Open Access

  File
• 2019

  Protein Kinase C Beta II Peptide Inhibitor Elicits Potent Cardioprotective Effects on Attenuating Ischemia/Reperfusion Injury

  Dang, J., Metellus, D., Lipscomb, C., Ebo, C., Nair, A., Patel, H., Humayun, A., Michaels, M., Finnegan, M., Dean, T., Checchio, L., Muftau-Lediju, F., Martorana, R. M., Mcintyre, A., Chen, Q., Barsotti, R. J. & Young, L. H., Nov 2019.

  Research output: Contribution to conference › Presentation

• Protein Kinase C Beta II Peptide Inhibitor Elicits Robust Effects on Attenuating Myocardial Ischemia/Reperfusion Injury

  Metellus, D., Lipscombe, C., Ebo, C., Nair, A., Patel, H., Humayun, A., Dang, J., Michaels, M., Finnegan, M., Checchio, L., Muftau-Lediju, F., Martorana, F., McIntyre, A., Chen, Q., Barsotti, R. J. & Young, L. H., May 8 2019.

  Research output: Contribution to conference › Presentation

  Open Access

  File

• The Effects of Metformin, Aminoguanidine, and Pyridoxamine on Methylglyoxal Induced Cardiac Myocyte Injury

  Harvey, A., Martorana, R., Colangeli, J., Ahmed, H., Delgado, D., Kim, A., Sandhu, R., Barsotti, R. J., Young, L. H. & Chen, Q., May 8 2019.

  Research output: Contribution to conference › Presentation

  Open Access

  File

• The Effects of Protein Kinase C Beta II Peptide Modulation on Superoxide Release in Rat Polymorphonuclear Leukocytes

  Lipscombe, C., Ebo, C., Metellus, D., Dang, J., Humayun, A., Nair, A., Patel, H., Michaels, M., Finnegan, M., Checchio, L., Muftau-Lediju, F., Martorana, F., Chen, Q., Barsotti, R. J. & Young, L. H., May 8 2019.

  Research output: Contribution to conference › Presentation

  Open Access

  File
• 2018

  Cardioprotective effects by a novel opioid peptide in myocardial ischemia/reperfusion injury

  Kim, H., McIntyre, A., Woodley, J., Lopez, A., Dittakavi, T., Finnegan, M., Amuquandoh, K., Ambrosino, M., Walker, K., Patel, H., Chen, Q., Barsotti, R. J. & Young, L., Apr 2018.

  Research output: Contribution to conference › Presentation

• Comparing the efficacy of pharmacological preconditioning with myristic acid-conjugated, TAT- conjugated and native protein kinase C epsilon peptide activator in myocardial ischemia/reperfusion (MI/R) Models

  McIntyre, A., Kim, H., Finnegan, M., Amuquandoh, K., Chen, Q., Barsotti, R. J. & Young, L., Apr 2018.

  Research output: Contribution to conference › Presentation

• Modulation of Nitric Oxide Release in Cultured Human Umbilical Vein Endothelial Cells by Myristoylated-PKC Epsilon Activator/Inhibitor Peptides

  Ajene, G., Dean, T., Thompson, C., Hwang, W., Jenney, F., Barsotti, R. J., Chen, Q. & Young, L. H., May 9 2018.

  Research output: Contribution to conference › Presentation

  Open Access

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• Modulation of nitric oxide release in human umbilical vein endothelial cells by myristolated-PKC epsilon activator/inhibitor peptides

  Dean, T., Hwang, W., Ajene, G., Bamimore, M., Chen, Q., Barsotti, R. J. & Young, L., Apr 2018.

  Research output: Contribution to conference › Presentation

• Synergistic Effects of Methylglyoxal and Hyperglycemia on ROS Generation and the Viability of Cultured H9c2 Myoblast Cells

  Sandhu, R., Lefkovitz, D., Ibe, A., Kim, A., Wieczorek, P., Delgado, D., Barsotti, R. J., Young, L. H. & Chen, Q., May 9 2018.

  Research output: Contribution to conference › Presentation

  Open Access

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• The cardioprotective potential of caffeic acid phenethyl ester (CAPE) on H2O2-induced H9C2 cell damage compared to common anti-oxidants

  Lefkowitz, D. S., Sanhu, R., Kim, A., Wieczorek, P., Barsotti, R. J., Young, L. & Chen, Q., Apr 2018.

  Research output: Contribution to conference › Presentation

• The Effect of Caffeic Acid Phenethyl Ester (CAPE) on H2O2-Induced Oxidative Stress in Cultured H9c2 Cells Compared to Common Antioxidants

  Lefkowitz, D., Sandhu, R., Kim, A., Castellano, A., Wieczorek, P., Barsotti, R. J., Young, L. H. & Chen, Q., May 9 2018.

  Research output: Contribution to conference › Presentation

  Open Access

  File

• The effects of metformin on methylglyoxal-induced cardiomyocytes cell damage

  Sandhu, R., Lefkovitz, D., Kim, A., Wieczorek, P., Barsotti, R. J., Young, L. & Chen, Q., Apr 2018.

  Research output: Contribution to conference › Presentation

• The Role of Autophagy During Myocardial Ischemia/Reperfusion Injury

  Ibe, A., Kim, A., Kim, H., Daniels, M., Young, L. H., Barsotti, R. J. & Chen, Q., May 9 2018.

  Research output: Contribution to conference › Presentation

  Open Access

  File

• The Role of Autophagy During Myocardial Ischemia/Reperfusion Injury

  Ibe, A., McIntyre, A., Kim, H., Castellano, A., Young, L., Barsotti, R. J. & Chen, Q., Apr 2018.

  Research output: Contribution to conference › Presentation
• 2017

  The Effects of Caffeic Acid Phenethyl Ester (Cape) on Oxidative Stress and Hypoxia

  Martin, S., Castellano, A., Uzoaru, C., Lim, J., Carvis, N., Wieczorek, P., Barsotti, R., Young, L. H. & Chen, Q., May 3 2017.

  Research output: Contribution to conference › Presentation

  Open Access

  File
• 2016

  Comparing the effectiveness of TAT and myristoylation of gp91ds on leukocyte superoxide (SO) release

  Patel, H., Bartol, K., Bottex, A., Remarcke, R., Chau, W., Walker, S., Chen, Q. & Barsotti, R., May 11 2016.

  Research output: Contribution to conference › Presentation

  Open Access

  File

• Determination of regional coronary flow utilizing microspheres in ex vivo myocardial ischemia/reperfusion (MI/R) injury

  Kuhn, T., Clark, S., Castellano, A., Kuo, D., Liu, S., Chen, Q. & Barsotti, R., May 11 2016.

  Research output: Contribution to conference › Presentation

  Open Access

  File

• Effects of Mitochondrial-Targeted Antioxidants on Real-Time Blood Nitric Oxide and Hydrogen Peroxide Release in Acute Hyperglycemia Rats

  Bertolet, M., Minni, M., Galbreath, T., Barsotti, R., Young, L. & Chen, Q., May 11 2016.

  Research output: Contribution to conference › Presentation

  Open Access

  File

• Investigating the Role of Mitochondrial Fission in Cardiac Myocyte Hypoxia/Re-oxygenation-Induced Cell Death

  Pratt, A., Heine, E., Chen, Q. & Barsotti, R., May 11 2016.

  Research output: Contribution to conference › Presentation

  Open Access

  File

• Myristoylated protein kinase C beta II peptide inhibitor exerts dose-dependent inhibition of N-formyl-L-methionyl-L-leucyl-L-phenylalanine (fMLP)-induced leukocyte superoxide release

  Ebo, C., Schmidgall, C., Lipscombe, C., Patel, H., Chen, Q. & Barsotti, R., May 11 2016.

  Research output: Contribution to conference › Presentation

  Open Access

  File

• Protein kinase C (PKC) delta activation negatively regulates phorbol 12-myristate 13-acetate (PMA) induced superoxide (SO) release in polymorphonuclear leukocytes (PMNs)

  Liu, S., Percy, S., Johannson, S., Adekayode, C., Stoner, G., Bottex, A., Adams, J., Barsotti, R. & Chen, Q., May 11 2016.

  Research output: Contribution to conference › Presentation

  Open Access

  File

• Protein kinase C beta II (PKC ßII) peptide inhibitor exerts cardioprotective effects in myocardial ischemia/reperfusion injury

  Lipscombe, C., Benjamin, I., Stutzman, D., Bottex, A., Ebo, C., Chen, Q. & Barsotti, R., May 11 2016.

  Research output: Contribution to conference › Presentation

  Open Access

  File

• The cardioprotective effects of caffeic acid phenethyl ester (CAPE) on myocardial ischemia/reperfusion (I/R) injury

  Castellano, A., Kuhn, T., Liu, S., Kucharski, K., Venditto, J., Kuo, D., Barsotti, R., Young, L. & Chen, Q., May 11 2016.

  Research output: Contribution to conference › Presentation

  Open Access

  File

• The Effectiveness of Coenzyme Q1 and Q10 in Mitigating Myocardial Reperfusion/Ischemia (MI/R) Injury

  Ashitey, M., Sutton, J., Venditto, J., Kucharski, K., Robbie, J., Kuo, D., Barsotti, R., Young, L. & Chen, Q., May 11 2016.

  Research output: Contribution to conference › Presentation

  Open Access

  File
• 2015

  Comparison of the Effects of Myristoylated and Transactivating Peptide (TAT) Conjugated Mitochondrial Fission Peptide Inhibitor (P110) in Myocardial Ischemia/Reperfusion (I/R) Injury

  Benjamin, I., Vu, J., Lipscombe, C., Stutzman, D., Schmigdall, C., Patel, H., Chen, Q., Hatcher, C. J., Barsotti, R. & Young, L. H., Jan 1 2015.

  Research output: Contribution to conference › Presentation

• Mdivi-1 exerts cardioprotective effects in myocardial ischemia/reperfusion (MI/R) when given at reperfusion.

  Stutzman, D., Schmidgall, C., Benjamin, I., Chen, Q., Hatcher, C., Barsotti, R. & Young, L., May 13 2015.

  Research output: Contribution to conference › Presentation

• Protein Kinase C (PKC) Delta Activator Attenuates NG-Nitro-L-Arginine-Methyl-Ester (L-NAME) Induced Leukocyte-Endothelial Interactions in Rat Mesenteric Post-Capillary Venules

  Pham, H., Bottex, A., Koon, A., Adams, J., Chen, Q., Barsotti, R. & Young, L., May 13 2015.

  Research output: Contribution to conference › Presentation