Projects per year
Personal profile
About
Dr. Ruth Borghaei is a professor in the Department of Bio-Medical Sciences.
Research interests
Dr. Borghaei's research interest is in transcriptional regulation of gene expression, particularly in response to inflammation. In addition, her lab is also interested in studying mechanisms behind epigenetic changes that occur in chronic inflammation, and may be involved in increased risk of carcinogenesis.
Related documents
Education/Academic qualification
Microbiology and Immunology, PhD, Temple University School of Medicine
… → 1992
Microbiology, BS, University of Maine
… → 1987
ASJC Scopus Subject Areas
- Biochemistry, medical
- Molecular Biology
Disciplines
- Molecular Biology
- Medical Biochemistry
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Regulation of DNA methylation and demethylation by inflammatory cytokines
Borghaei, R. C. (PI)
1/1/15 → …
Project: Research project
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Transcriptional regulation of matrix metalloproteinase 3
Borghaei, R. C. (PI)
1/1/04 → 1/1/10
Project: Research project
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IL-1 Regulation of MMP Genes in Human Gingival Fibroblasts
Borghaei, R. C. (PI)
1/1/97 → 1/1/03
Project: Research project
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IL-1 Regulation of MMP Genes in Human Gingival Fibroblasts
Borghaei, R. C. (PI)
1/1/95 → 1/1/97
Project: Research project
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Transcriptional regulation of c-Jun expression during late G1/S in normal human cells is lost in human tumor cells
Borghaei, R. C., Yumet, G., Peña, A., Soprano, D. R. & Soprano, K. J., Sep 2994, In: Oncogene. 9Research output: Contribution to journal › Article › peer-review
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Role of TET1 inhibition in IL-1 augmentation of TGF-B induced Epithelial to Mesenchymal transition in A549 lung adenocarcinoma cells
Rojek, O., Seutter, S., Hensley, K. & Borghaei, R. C., Apr 17 2026.Research output: Contribution to conference › Poster
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Augmentation of Transforming Growth Factor-β-induced Epithelial to Mesenchymal Transition by Interleukin-1β: Role of DNA Methylation
Hensley, K., Seutter, S. & Borghaei, R. C., Apr 30 2025.Research output: Contribution to conference › Poster
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Assessing the effects of a novel metalloprotease inhibitor, extracellular matrix protection factor-2, on primary human gingival fibroblast's metabolic viability as determined by total protein production
Maloney, T., Mattioli, P., Laird, P., Musiol, J., Popper, H., Otto, A., Green, K., Shamseddin, S., Borghaei, R. & D'Angelo, M., May 10 2021.Research output: Contribution to conference › Presentation
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Measurement of collagen metabolism and metalloprotease production demonstrates that primary human gingival fibroblasts retain inflamed tissue profile in serum free culture
Musiol, J., Laird, P., Mattioli, P., Maloney, T., Popper, H., Otto, A., Isaac, T., Nguyen, S., Morris, G., Shamseddin, S., Green, K., Borghaei, R. & D'Angelo, M., May 10 2021.Research output: Contribution to conference › Presentation
Activities
- 3 Membership of network
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Sigma Xi - PCOM Chapter (External organization)
Borghaei, R. C. (Member)
2000 → …Activity: Membership › Membership of network
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American Society of Genetics (External organization)
Borghaei, R. C. (Member)
2000 → …Activity: Membership › Membership of network
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American Society for Biochemistry and Molecular Biology (External organization)
Borghaei, R. C. (Member)
2000 → …Activity: Membership › Membership of network