A Novel Air-Jet Dry Powder Insufflator for High Efficiency Aerosol Delivery to Small Animals

M Momin; DR Farkas; Rudra Pangeni; A Hassan; CJ Dalton; S Poudel; F Hall; Q Xu; P Longest; M Hindle

A Novel Air-Jet Dry Powder Insufflator for High Efficiency Aerosol Delivery to Small Animals

M Momin
, DR Farkas
, Rudra Pangeni
, A Hassan
, CJ Dalton
, S Poudel
, F Hall
, Q Xu
, P Longest
, M Hindle

Department of Pharmaceutical Sciences

Research output: Contribution to journal › Meeting abstract

Abstract

The objective of this study is to describe a novel dry powder insufflator (DPI) developed for the delivery of powder aerosols to a small animal model (rat). In vitro and in vivo performance evaluation of the DPI will be described and a series of formulation applications will be presented. The basic components of the air-jet DPI for rat delivery (Rat AJ DPI) are an air source, air-jet aerosolization engine and delivery cannula with safety wedge. In order to benchmark the new device, we compared the in vitro and in vivo aerosol performance of the Rat AJ DPI with the Penn-Century DP-4 DPI (which is no longer commercially available) using a model albuterol spray dried formulation at different delivered doses. We also evaluated the in vitro and in vivo performance of the Rat AJ DPI using other spray dried formulations (tobramycin and a lung surfactant) to explore its ability to deliver a variety of dry powder aerosols. The Rat AJ DPI demonstrated efficient emptying and small-particle aerosol generation making it suitable for preclinical powder formulation evaluation in rat animal models.

Original language	American English
Pages (from-to)	46-53
Journal	RDD Asia
Volume	1
State	Published - 2024

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Cite this

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title = "A Novel Air-Jet Dry Powder Insufflator for High Efficiency Aerosol Delivery to Small Animals",

abstract = "The objective of this study is to describe a novel dry powder insufflator (DPI) developed for the delivery of powder aerosols to a small animal model (rat). In vitro and in vivo performance evaluation of the DPI will be described and a series of formulation applications will be presented. The basic components of the air-jet DPI for rat delivery (Rat AJ DPI) are an air source, air-jet aerosolization engine and delivery cannula with safety wedge. In order to benchmark the new device, we compared the in vitro and in vivo aerosol performance of the Rat AJ DPI with the Penn-Century DP-4 DPI (which is no longer commercially available) using a model albuterol spray dried formulation at different delivered doses. We also evaluated the in vitro and in vivo performance of the Rat AJ DPI using other spray dried formulations (tobramycin and a lung surfactant) to explore its ability to deliver a variety of dry powder aerosols. The Rat AJ DPI demonstrated efficient emptying and small-particle aerosol generation making it suitable for preclinical powder formulation evaluation in rat animal models.",

author = "M Momin and DR Farkas and Rudra Pangeni and A Hassan and CJ Dalton and S Poudel and F Hall and Q Xu and P Longest and M Hindle",

year = "2024",

language = "American English",

volume = "1",

pages = "46--53",

journal = "RDD Asia",

}

TY - JOUR

T1 - A Novel Air-Jet Dry Powder Insufflator for High Efficiency Aerosol Delivery to Small Animals

AU - Momin, M

AU - Farkas, DR

AU - Pangeni, Rudra

AU - Hassan, A

AU - Dalton, CJ

AU - Poudel, S

AU - Hall, F

AU - Xu, Q

AU - Longest, P

AU - Hindle, M

PY - 2024

Y1 - 2024

N2 - The objective of this study is to describe a novel dry powder insufflator (DPI) developed for the delivery of powder aerosols to a small animal model (rat). In vitro and in vivo performance evaluation of the DPI will be described and a series of formulation applications will be presented. The basic components of the air-jet DPI for rat delivery (Rat AJ DPI) are an air source, air-jet aerosolization engine and delivery cannula with safety wedge. In order to benchmark the new device, we compared the in vitro and in vivo aerosol performance of the Rat AJ DPI with the Penn-Century DP-4 DPI (which is no longer commercially available) using a model albuterol spray dried formulation at different delivered doses. We also evaluated the in vitro and in vivo performance of the Rat AJ DPI using other spray dried formulations (tobramycin and a lung surfactant) to explore its ability to deliver a variety of dry powder aerosols. The Rat AJ DPI demonstrated efficient emptying and small-particle aerosol generation making it suitable for preclinical powder formulation evaluation in rat animal models.

AB - The objective of this study is to describe a novel dry powder insufflator (DPI) developed for the delivery of powder aerosols to a small animal model (rat). In vitro and in vivo performance evaluation of the DPI will be described and a series of formulation applications will be presented. The basic components of the air-jet DPI for rat delivery (Rat AJ DPI) are an air source, air-jet aerosolization engine and delivery cannula with safety wedge. In order to benchmark the new device, we compared the in vitro and in vivo aerosol performance of the Rat AJ DPI with the Penn-Century DP-4 DPI (which is no longer commercially available) using a model albuterol spray dried formulation at different delivered doses. We also evaluated the in vitro and in vivo performance of the Rat AJ DPI using other spray dried formulations (tobramycin and a lung surfactant) to explore its ability to deliver a variety of dry powder aerosols. The Rat AJ DPI demonstrated efficient emptying and small-particle aerosol generation making it suitable for preclinical powder formulation evaluation in rat animal models.

M3 - Meeting abstract

VL - 1

SP - 46

EP - 53

JO - RDD Asia

JF - RDD Asia

ER -