Aluminium chloride-induced hippocampal damage: CA3 hippocampal subfield involvement and the neuroprotective role of Buchholzia coriacea ethanolic seed extract

Stephen Taiye Adelodun; Oluwadamilola Adunni Ishola; Ayodeji Zabdiel Abijo; Sunday Yinka Olatunji; Joshua Owolabi; John Afees Olanrewaju; Damilare Adedayo Adekomi

doi:10.1016/j.phyplu.2021.100104

Aluminium chloride-induced hippocampal damage: CA3 hippocampal subfield involvement and the neuroprotective role of Buchholzia coriacea ethanolic seed extract

Stephen Taiye Adelodun, Oluwadamilola Adunni Ishola, Ayodeji Zabdiel Abijo, Sunday Yinka Olatunji, Joshua Owolabi, John Afees Olanrewaju, Damilare Adedayo Adekomi

Department of Bio-Medical Sciences (PCOM)

Research output: Contribution to journal › Article › peer-review

Abstract

 Background
 Early signs of neurodegenerative events of Alzheimer's disease manifest within the hippocampus and presents as cognitive and memory impairment. Aluminium-chloride (AlCl   3  ), a neurotoxicant interferes with the structure and functions of the hippocampus as well as its       neurogenesis    , thereby causing cognitive and memory impairment.    Buchholzia coriacea   (BC), a plant of       nutraceutical     value is traditionally reputed to boost memory and cognitive functions. This study elucidated the       neuroprotective     role of    Buchholzia coriacea   seed extract on AlCl   3  -induced hippocampal neuronal damage in Wistar rat model by examining the biochemical, histological, immunohistochemical, and neurobehavioural changes.
 Methods
 Twenty-five male Wistar rats were randomly assigned into five groups A-E (n = 5). Group A served as the control, groups B-E were given 200 mg/kg of AlCl   3   for 14 days and then received 2 mLs/kg distilled water, 50mg/kg BC, 100mg/kg BC and 2.5mg/kg       donepezil     respectively for 14 days orally.       Glutathione     and neurotransmitters (Glutamate, dopamine, and acetylcholine) levels, G6PDH and neurobehavioral activities, as well as histological (H and E, LFB and       Cresyl violet     stains) and immunohistochemical (ionized calcium-binding adapter molecule 1, Iba-1) changes were evaluated
 Results
 AlCl   3   impaired spatial working memory with observable improvements in the treated groups.       Enzymatic activity     and       neurotransmitter     levels were augmented in the group treated with the highest dose of BC compared to the control. Histological assessment showed that BC high-dose mitigated neurodegenerative changes in the CA3 hippocampal subfield.
 Conclusion
 Taken together, BC exhibited neuroprotective ability on AlCl   3  -induced CA3 hippocampal field neuronal damage and demonstrated memory impairment reversing ability.

Original language	American English
Journal	Phytomedicine Plus
Volume	1
DOIs	https://doi.org/10.1016/j.phyplu.2021.100104
State	Published - 2021

Disciplines

Medicine and Health Sciences

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@article{ec6d63866a284783bdef7039eda2550e,

title = "Aluminium chloride-induced hippocampal damage: CA3 hippocampal subfield involvement and the neuroprotective role of Buchholzia coriacea ethanolic seed extract",

abstract = " Background Early signs of neurodegenerative events of Alzheimer's disease manifest within the hippocampus and presents as cognitive and memory impairment. Aluminium-chloride (AlCl 3 ), a neurotoxicant interferes with the structure and functions of the hippocampus as well as its neurogenesis , thereby causing cognitive and memory impairment. Buchholzia coriacea (BC), a plant of nutraceutical value is traditionally reputed to boost memory and cognitive functions. This study elucidated the neuroprotective role of Buchholzia coriacea seed extract on AlCl 3 -induced hippocampal neuronal damage in Wistar rat model by examining the biochemical, histological, immunohistochemical, and neurobehavioural changes. Methods Twenty-five male Wistar rats were randomly assigned into five groups A-E (n = 5). Group A served as the control, groups B-E were given 200 mg/kg of AlCl 3 for 14 days and then received 2 mLs/kg distilled water, 50mg/kg BC, 100mg/kg BC and 2.5mg/kg donepezil respectively for 14 days orally. Glutathione and neurotransmitters (Glutamate, dopamine, and acetylcholine) levels, G6PDH and neurobehavioral activities, as well as histological (H and E, LFB and Cresyl violet stains) and immunohistochemical (ionized calcium-binding adapter molecule 1, Iba-1) changes were evaluated Results AlCl 3 impaired spatial working memory with observable improvements in the treated groups. Enzymatic activity and neurotransmitter levels were augmented in the group treated with the highest dose of BC compared to the control. Histological assessment showed that BC high-dose mitigated neurodegenerative changes in the CA3 hippocampal subfield. Conclusion Taken together, BC exhibited neuroprotective ability on AlCl 3 -induced CA3 hippocampal field neuronal damage and demonstrated memory impairment reversing ability.",

author = "Adelodun, {Stephen Taiye} and Ishola, {Oluwadamilola Adunni} and Abijo, {Ayodeji Zabdiel} and Olatunji, {Sunday Yinka} and Joshua Owolabi and Olanrewaju, {John Afees} and Adekomi, {Damilare Adedayo}",

year = "2021",

doi = "10.1016/j.phyplu.2021.100104",

language = "American English",

volume = "1",

journal = "Phytomedicine Plus",

}

TY - JOUR

T1 - Aluminium chloride-induced hippocampal damage: CA3 hippocampal subfield involvement and the neuroprotective role of Buchholzia coriacea ethanolic seed extract

AU - Adelodun, Stephen Taiye

AU - Ishola, Oluwadamilola Adunni

AU - Abijo, Ayodeji Zabdiel

AU - Olatunji, Sunday Yinka

AU - Owolabi, Joshua

AU - Olanrewaju, John Afees

AU - Adekomi, Damilare Adedayo

PY - 2021

Y1 - 2021

N2 - Background Early signs of neurodegenerative events of Alzheimer's disease manifest within the hippocampus and presents as cognitive and memory impairment. Aluminium-chloride (AlCl 3 ), a neurotoxicant interferes with the structure and functions of the hippocampus as well as its neurogenesis , thereby causing cognitive and memory impairment. Buchholzia coriacea (BC), a plant of nutraceutical value is traditionally reputed to boost memory and cognitive functions. This study elucidated the neuroprotective role of Buchholzia coriacea seed extract on AlCl 3 -induced hippocampal neuronal damage in Wistar rat model by examining the biochemical, histological, immunohistochemical, and neurobehavioural changes. Methods Twenty-five male Wistar rats were randomly assigned into five groups A-E (n = 5). Group A served as the control, groups B-E were given 200 mg/kg of AlCl 3 for 14 days and then received 2 mLs/kg distilled water, 50mg/kg BC, 100mg/kg BC and 2.5mg/kg donepezil respectively for 14 days orally. Glutathione and neurotransmitters (Glutamate, dopamine, and acetylcholine) levels, G6PDH and neurobehavioral activities, as well as histological (H and E, LFB and Cresyl violet stains) and immunohistochemical (ionized calcium-binding adapter molecule 1, Iba-1) changes were evaluated Results AlCl 3 impaired spatial working memory with observable improvements in the treated groups. Enzymatic activity and neurotransmitter levels were augmented in the group treated with the highest dose of BC compared to the control. Histological assessment showed that BC high-dose mitigated neurodegenerative changes in the CA3 hippocampal subfield. Conclusion Taken together, BC exhibited neuroprotective ability on AlCl 3 -induced CA3 hippocampal field neuronal damage and demonstrated memory impairment reversing ability.

AB - Background Early signs of neurodegenerative events of Alzheimer's disease manifest within the hippocampus and presents as cognitive and memory impairment. Aluminium-chloride (AlCl 3 ), a neurotoxicant interferes with the structure and functions of the hippocampus as well as its neurogenesis , thereby causing cognitive and memory impairment. Buchholzia coriacea (BC), a plant of nutraceutical value is traditionally reputed to boost memory and cognitive functions. This study elucidated the neuroprotective role of Buchholzia coriacea seed extract on AlCl 3 -induced hippocampal neuronal damage in Wistar rat model by examining the biochemical, histological, immunohistochemical, and neurobehavioural changes. Methods Twenty-five male Wistar rats were randomly assigned into five groups A-E (n = 5). Group A served as the control, groups B-E were given 200 mg/kg of AlCl 3 for 14 days and then received 2 mLs/kg distilled water, 50mg/kg BC, 100mg/kg BC and 2.5mg/kg donepezil respectively for 14 days orally. Glutathione and neurotransmitters (Glutamate, dopamine, and acetylcholine) levels, G6PDH and neurobehavioral activities, as well as histological (H and E, LFB and Cresyl violet stains) and immunohistochemical (ionized calcium-binding adapter molecule 1, Iba-1) changes were evaluated Results AlCl 3 impaired spatial working memory with observable improvements in the treated groups. Enzymatic activity and neurotransmitter levels were augmented in the group treated with the highest dose of BC compared to the control. Histological assessment showed that BC high-dose mitigated neurodegenerative changes in the CA3 hippocampal subfield. Conclusion Taken together, BC exhibited neuroprotective ability on AlCl 3 -induced CA3 hippocampal field neuronal damage and demonstrated memory impairment reversing ability.

U2 - 10.1016/j.phyplu.2021.100104

DO - 10.1016/j.phyplu.2021.100104

M3 - Article

VL - 1

JO - Phytomedicine Plus

JF - Phytomedicine Plus

ER -