Anatomical Evidence of Systemic Progression in Desmoplastic Small Cell Round Tumor

BACKGROUND: Desmoplastic small round cell tumor (DSCRT) is a rare and aggressive malignant neoplasm with characteristic intra-abdominal involvement and poor prognosis. Existing literature focuses on known presentations of DSCRT and current treatment outcomes, while cadaveric anatomical findings remain underexplored.

OBJECTIVE: This case report aims to characterize anatomical and lymphatic manifestations of advanced DSCRT through cadaveric dissection and quantitative comparison with other cadavers whose causes of death were malignant in nature.

METHODS: A cadaveric case study was conducted through anatomical dissection. Quantitative assessment included lymph node counts and measurements, evaluation of metastatic extent, and documentation of gross anatomical changes within the abdominal viscera. These observations were compared with other cadavers with malignancies listed as their cause of death.

RESULTS: Cadaver 19 exhibited consistently elevated lymph node counts and mean lymph node dimensions compared to over 40 cadavers across multiple cohorts with malignant causes of death. Additionally, extensive lesions throughout the small and large intestines and marked bile stasis were noted on macroscopic examination.

CONCLUSION: This cadaveric case highlights the metastatic patterns and impact of DSCRT and underscores the necessity of further investigation into its anatomical manifestations and clinical implications.