Assessing Changes in BDNF as a Correlate to Memory Following Chronic Methamphetamine Administration

Vanessa Louis; Adwoa Aduonum

Assessing Changes in BDNF as a Correlate to Memory Following Chronic Methamphetamine Administration

Department of Bio-Medical Sciences (PCOM)

Research output: Other contribution

Abstract

Background: The neurotrophin brain derived neurotrophic factor (BDNF) has emerged as a key participant in cognitive processes, such as learning and memory. It is recognized as an effector immediate early gene (IEG) capable of influencing synaptic activity pre- and post synaptically. Methamphetamine (METH) is a psychostimulant that disrupts activity at the synapse. This interruption causes alterations in monoamines and IEGs related to learning and memory in the hippocampus. METH users are known to perform subpar than controls on tasks of verbal/nonverbal memory and recognition, but the mechanisms that underlie these disturbances are unclear.

Original language	American English
State	Published - May 2 2012

Keywords

Methamphetamine
Brain-Derived Neurotrophic Factor
Memory

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Assessing Changes in BDNF as a Correlate to Memory Following ChroFinal published version, 73 KBLicense: CC BY

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title = "Assessing Changes in BDNF as a Correlate to Memory Following Chronic Methamphetamine Administration",

abstract = " Background: The neurotrophin brain derived neurotrophic factor (BDNF) has emerged as a key participant in cognitive processes, such as learning and memory. It is recognized as an effector immediate early gene (IEG) capable of influencing synaptic activity pre- and post synaptically. Methamphetamine (METH) is a psychostimulant that disrupts activity at the synapse. This interruption causes alterations in monoamines and IEGs related to learning and memory in the hippocampus. METH users are known to perform subpar than controls on tasks of verbal/nonverbal memory and recognition, but the mechanisms that underlie these disturbances are unclear.",

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AU - Aduonum, Adwoa

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N2 - Background: The neurotrophin brain derived neurotrophic factor (BDNF) has emerged as a key participant in cognitive processes, such as learning and memory. It is recognized as an effector immediate early gene (IEG) capable of influencing synaptic activity pre- and post synaptically. Methamphetamine (METH) is a psychostimulant that disrupts activity at the synapse. This interruption causes alterations in monoamines and IEGs related to learning and memory in the hippocampus. METH users are known to perform subpar than controls on tasks of verbal/nonverbal memory and recognition, but the mechanisms that underlie these disturbances are unclear.

AB - Background: The neurotrophin brain derived neurotrophic factor (BDNF) has emerged as a key participant in cognitive processes, such as learning and memory. It is recognized as an effector immediate early gene (IEG) capable of influencing synaptic activity pre- and post synaptically. Methamphetamine (METH) is a psychostimulant that disrupts activity at the synapse. This interruption causes alterations in monoamines and IEGs related to learning and memory in the hippocampus. METH users are known to perform subpar than controls on tasks of verbal/nonverbal memory and recognition, but the mechanisms that underlie these disturbances are unclear.

KW - Methamphetamine

KW - Brain-Derived Neurotrophic Factor

KW - Memory

UR - https://digitalcommons.pcom.edu/research_day/research_day2012/research/21

M3 - Other contribution

ER -

Assessing Changes in BDNF as a Correlate to Memory Following Chronic Methamphetamine Administration

Abstract

Keywords

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