Changes in Expression of Genes Associated with Autophagy and Apoptosis in Neuronal Cells Infected with HSV-1may Suggest Infection-induced Mechanisms of Neurodegeneration

Alexis Mark; Fiora D. Zoga; Brian J. Balin; Denah M. Appelt; Susan T. Hingley

Changes in Expression of Genes Associated with Autophagy and Apoptosis in Neuronal Cells Infected with HSV-1may Suggest Infection-induced Mechanisms of Neurodegeneration

Alexis Mark, Fiora D. Zoga, Brian J. Balin, Denah M. Appelt, Susan T. Hingley

Department of Bio-Medical Sciences (PCOM)

Research output: Other contribution

Abstract

Background: This study investigates the potential role of herpes simplex virus type 1 (HSV-1) in the pathogenesis of neurodegenerative disorders, such as Alzheimer’s disease (AD), by exploring changes in gene expression related to antiviral immunity and the autophagic pathway. Autophagy is a process that recycles organelles and proteins to create more energy for the cell. This pathway has been linked to neurodegeneration, as malfunctions in the completion of this process lead to a decline in overall cellular health and function. Interestingly, HSV-1 has been shown to block the completion of autophagy, which would potentially contribute to the cytopathic changes observed in AD.

Original language	American English
State	Published - May 2 2012

Keywords

Human Herpesvirus 1
Neurodegenerative Diseases
Gene Expression
Autophagy
Apoptosis

Disciplines

Medicine and Health Sciences

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Changes in Expression of Genes Associated with Autophagy and ApopFinal published version, 55 KBLicense: CC BY
Changes in Expression of Genes Associated with Autophagy and ApopFinal published version, 55 KBLicense: CC BY

Cite this

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title = "Changes in Expression of Genes Associated with Autophagy and Apoptosis in Neuronal Cells Infected with HSV-1may Suggest Infection-induced Mechanisms of Neurodegeneration",

abstract = " Background: This study investigates the potential role of herpes simplex virus type 1 (HSV-1) in the pathogenesis of neurodegenerative disorders, such as Alzheimer{\textquoteright}s disease (AD), by exploring changes in gene expression related to antiviral immunity and the autophagic pathway. Autophagy is a process that recycles organelles and proteins to create more energy for the cell. This pathway has been linked to neurodegeneration, as malfunctions in the completion of this process lead to a decline in overall cellular health and function. Interestingly, HSV-1 has been shown to block the completion of autophagy, which would potentially contribute to the cytopathic changes observed in AD.",

keywords = "Human Herpesvirus 1, Neurodegenerative Diseases, Gene Expression, Autophagy, Apoptosis",

author = "Alexis Mark and Zoga, {Fiora D.} and Balin, {Brian J.} and Appelt, {Denah M.} and Hingley, {Susan T.}",

year = "2012",

month = may,

day = "2",

language = "American English",

type = "Other",

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T1 - Changes in Expression of Genes Associated with Autophagy and Apoptosis in Neuronal Cells Infected with HSV-1may Suggest Infection-induced Mechanisms of Neurodegeneration

AU - Mark, Alexis

AU - Zoga, Fiora D.

AU - Balin, Brian J.

AU - Appelt, Denah M.

AU - Hingley, Susan T.

PY - 2012/5/2

Y1 - 2012/5/2

N2 - Background: This study investigates the potential role of herpes simplex virus type 1 (HSV-1) in the pathogenesis of neurodegenerative disorders, such as Alzheimer’s disease (AD), by exploring changes in gene expression related to antiviral immunity and the autophagic pathway. Autophagy is a process that recycles organelles and proteins to create more energy for the cell. This pathway has been linked to neurodegeneration, as malfunctions in the completion of this process lead to a decline in overall cellular health and function. Interestingly, HSV-1 has been shown to block the completion of autophagy, which would potentially contribute to the cytopathic changes observed in AD.

AB - Background: This study investigates the potential role of herpes simplex virus type 1 (HSV-1) in the pathogenesis of neurodegenerative disorders, such as Alzheimer’s disease (AD), by exploring changes in gene expression related to antiviral immunity and the autophagic pathway. Autophagy is a process that recycles organelles and proteins to create more energy for the cell. This pathway has been linked to neurodegeneration, as malfunctions in the completion of this process lead to a decline in overall cellular health and function. Interestingly, HSV-1 has been shown to block the completion of autophagy, which would potentially contribute to the cytopathic changes observed in AD.

KW - Human Herpesvirus 1

KW - Neurodegenerative Diseases

KW - Gene Expression

KW - Autophagy

KW - Apoptosis

UR - https://digitalcommons.pcom.edu/research_day/research_day2012/research/13

M3 - Other contribution

ER -

Changes in Expression of Genes Associated with Autophagy and Apoptosis in Neuronal Cells Infected with HSV-1may Suggest Infection-induced Mechanisms of Neurodegeneration

Abstract

Keywords

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