Covalent bonding of vancomycin to Ti6Al4V alloy pins provides long-term inhibition of Staphylococcus aureus colonization

O. P. Edupuganti; V. Antoci; S. B. King; B. Jose; Christopher S. Adams; J. Parvizi; I. M. Shapiro; A. R. Zeiger; N. J. Hickok; E. Wickstrom

Covalent bonding of vancomycin to Ti6Al4V alloy pins provides long-term inhibition of Staphylococcus aureus colonization

O. P. Edupuganti
, V. Antoci
, S. B. King
, B. Jose
, Christopher S. Adams
, J. Parvizi
, I. M. Shapiro
, A. R. Zeiger
, N. J. Hickok
, E. Wickstrom

Department of Bio-Medical Sciences (PCOM)

Research output: Contribution to journal › Article › peer-review

Abstract

Self-protecting Ti6Al4V alloy pins were prepared by covalent bonding of bis(ethylene glycol) linkers, then vancomycin to the oxidized, aminopropylated Ti6Al4V alloy surface. Fluorescence modification-enabled estimation of yields of free amines on the metallic surface monolayer at each reaction step. The vancomycin-protected Ti6Al4V pins were not colonized by Staphylococcus aureus, even after 44 days storage in physiological buffer. These results provide a basis for testing self-protection against S. aureus colonization in animal models. Â© 2007 Elsevier Ltd. All rights reserved.

Original language	American English
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	17
State	Published - Jan 1 2007

Keywords

Animalia
Antibiotics
Biofilms
Implants
Orthopedics
Solid phase synthesis
Staphylococcus aureus
Time
alloy
amine
article
bacterial colonization
bis(ethylene glycol)
buffer
controlled study
covalent bond
fluorescence
glycol
inhibition kinetics
nonhuman
orthopedic equipment
storage
titanium
unclassified drug
vancomycin

Disciplines

Life Sciences

Cite this

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title = "Covalent bonding of vancomycin to Ti6Al4V alloy pins provides long-term inhibition of Staphylococcus aureus colonization",

abstract = " Self-protecting Ti6Al4V alloy pins were prepared by covalent bonding of bis(ethylene glycol) linkers, then vancomycin to the oxidized, aminopropylated Ti6Al4V alloy surface. Fluorescence modification-enabled estimation of yields of free amines on the metallic surface monolayer at each reaction step. The vancomycin-protected Ti6Al4V pins were not colonized by Staphylococcus aureus, even after 44 days storage in physiological buffer. These results provide a basis for testing self-protection against S. aureus colonization in animal models. {\^A}{\textcopyright} 2007 Elsevier Ltd. All rights reserved.",

keywords = "Animalia, Antibiotics, Biofilms, Implants, Orthopedics, Solid phase synthesis, Staphylococcus aureus, Time, alloy, amine, article, bacterial colonization, bis(ethylene glycol), buffer, controlled study, covalent bond, fluorescence, glycol, inhibition kinetics, nonhuman, orthopedic equipment, storage, titanium, unclassified drug, vancomycin",

author = "Edupuganti, \{O. P.\} and V. Antoci and King, \{S. B.\} and B. Jose and Adams, \{Christopher S.\} and J. Parvizi and Shapiro, \{I. M.\} and Zeiger, \{A. R.\} and Hickok, \{N. J.\} and E. Wickstrom",

year = "2007",

month = jan,

day = "1",

language = "American English",

volume = "17",

journal = "Bioorganic and Medicinal Chemistry Letters",

}

TY - JOUR

T1 - Covalent bonding of vancomycin to Ti6Al4V alloy pins provides long-term inhibition of Staphylococcus aureus colonization

AU - Edupuganti, O. P.

AU - Antoci, V.

AU - King, S. B.

AU - Jose, B.

AU - Adams, Christopher S.

AU - Parvizi, J.

AU - Shapiro, I. M.

AU - Zeiger, A. R.

AU - Hickok, N. J.

AU - Wickstrom, E.

PY - 2007/1/1

Y1 - 2007/1/1

N2 - Self-protecting Ti6Al4V alloy pins were prepared by covalent bonding of bis(ethylene glycol) linkers, then vancomycin to the oxidized, aminopropylated Ti6Al4V alloy surface. Fluorescence modification-enabled estimation of yields of free amines on the metallic surface monolayer at each reaction step. The vancomycin-protected Ti6Al4V pins were not colonized by Staphylococcus aureus, even after 44 days storage in physiological buffer. These results provide a basis for testing self-protection against S. aureus colonization in animal models. Â© 2007 Elsevier Ltd. All rights reserved.

AB - Self-protecting Ti6Al4V alloy pins were prepared by covalent bonding of bis(ethylene glycol) linkers, then vancomycin to the oxidized, aminopropylated Ti6Al4V alloy surface. Fluorescence modification-enabled estimation of yields of free amines on the metallic surface monolayer at each reaction step. The vancomycin-protected Ti6Al4V pins were not colonized by Staphylococcus aureus, even after 44 days storage in physiological buffer. These results provide a basis for testing self-protection against S. aureus colonization in animal models. Â© 2007 Elsevier Ltd. All rights reserved.

KW - Animalia

KW - Antibiotics

KW - Biofilms

KW - Implants

KW - Orthopedics

KW - Solid phase synthesis

KW - Staphylococcus aureus

KW - Time

KW - alloy

KW - amine

KW - article

KW - bacterial colonization

KW - bis(ethylene glycol)

KW - buffer

KW - controlled study

KW - covalent bond

KW - fluorescence

KW - glycol

KW - inhibition kinetics

KW - nonhuman

KW - orthopedic equipment

KW - storage

KW - titanium

KW - unclassified drug

KW - vancomycin

UR - https://digitalcommons.pcom.edu/scholarly_papers/1561

M3 - Article

VL - 17

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

ER -

Covalent bonding of vancomycin to Ti6Al4V alloy pins provides long-term inhibition of Staphylococcus aureus colonization

Abstract

Keywords

Disciplines

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