Cutting-Edge Technologies for Ovarian Cancer: An Overview of the Impact of Genetic Testing, Next-Generation Sequencing, and Single-Cell Analysis

Cancer genetics is increasingly becoming central in the course of patients’ care. Genetic testing for pathogenic variants in ovarian cancer (OC) is becoming widely available and represents a cornerstone for cancer risk assessment, prediction of prognosis, and targeted treatments. The introduction of novel technologies for sequencing has enabled large-scale multigene panel genomic testing. In this chapter, the current genetic variants and genetic testing guidelines for OC are reviewed. We also discussed potential applications of next-generation sequencing in understanding OC genetics and its impact on patients’ outcomes according to the latest research findings. We finally depict the potential of single-cell sequencing in understanding OC heterogeneity based on recent proof-of-concept studies.