Down-regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase mRNA levels and synthesis in Syrian hamster C100 cells by the oxidosqualene cyclase inhibitor [4'-(6-allyl-ethyl-amino-hexyloxy)-2'-fluoro-phenyl]-(4-bromophenyl) -methanone (Ro 48-8071) : Comparison to simvastatin

TY - JOUR

T1 - Down-regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase mRNA levels and synthesis in Syrian hamster C100 cells by the oxidosqualene cyclase inhibitor [4'-(6-allyl-ethyl-amino-hexyloxy)-2'-fluoro-phenyl]-(4-bromophenyl) -methanone (Ro 48-8071) : Comparison to simvastatin

AU - Peffley, Dennis M.

AU - Gayen, Apurba K.

AU - Morand, Olivier H.

N1 - JavaScript is disabled on your browser. Please enable JavaScript to use all the features on this page. In vivo inhibition of 2,3-oxidosqualene:lanosterol cyclase (OSC, E.C. 5.4.99.7)-the enzyme which catalyzes the cyclization of monooxidosqualene to lanosterol-does not result in elevated 3-hydroxy-3-methylglutaryl CoA reductase (HMGR) activity.

PY - 1998/1/8

Y1 - 1998/1/8

UR - https://www.sciencedirect.com/science/article/pii/S0006295298000835

U2 - 10.1016/S0006-2952(98)00083-5

DO - 10.1016/S0006-2952(98)00083-5

M3 - Article

VL - 56

JO - Biochemical Pharmacology

JF - Biochemical Pharmacology

ER -