Effects of dexamethasone on phospholipase activities in palate mesenchyme cells in vitro.

K P Chepenik; Mindy George-Weinstein; R M Greene

Effects of dexamethasone on phospholipase activities in palate mesenchyme cells in vitro.

K P Chepenik, Mindy George-Weinstein, R M Greene

Division of Research

Research output: Contribution to journal › Article › peer-review

Abstract

Treatment of primary cultures of palate mesenchyme cells from AJAX strain embryos with dexamethasone inhibited only phospholipase activity expressed at pH 7.5. A similar treatment did not have such an effect on palate mesenchyme cells from C57BL/6J strain embryos. Since the AJAX strain embryo is sensitive to the induction of cleft palate by exogenous glucocorticoids and the C57BL/6J strain is less so, these data allow consideration of phospholipase activity as a site of regulation for development of the palate.

Original language	American English
Journal	Teratology
Volume	32
State	Published - Aug 1 1985

Keywords

Animals
Cells
Cultured
Dexamethasone
Hydrogen-Ion Concentration
Inbred Strains
Mice
Palate
Phospholipases

Disciplines

Medicine and Health Sciences

Cite this

@article{3f86ed670e7843bd996cd5993aeb0662,

title = "Effects of dexamethasone on phospholipase activities in palate mesenchyme cells in vitro.",

abstract = " Treatment of primary cultures of palate mesenchyme cells from AJAX strain embryos with dexamethasone inhibited only phospholipase activity expressed at pH 7.5. A similar treatment did not have such an effect on palate mesenchyme cells from C57BL/6J strain embryos. Since the AJAX strain embryo is sensitive to the induction of cleft palate by exogenous glucocorticoids and the C57BL/6J strain is less so, these data allow consideration of phospholipase activity as a site of regulation for development of the palate.",

keywords = "Animals, Cells, Cultured, Dexamethasone, Hydrogen-Ion Concentration, Inbred Strains, Mice, Palate, Phospholipases",

author = "Chepenik, \{K P\} and Mindy George-Weinstein and Greene, \{R M\}",

year = "1985",

month = aug,

day = "1",

language = "American English",

volume = "32",

journal = "Teratology",

}

TY - JOUR

T1 - Effects of dexamethasone on phospholipase activities in palate mesenchyme cells in vitro.

AU - Chepenik, K P

AU - George-Weinstein, Mindy

AU - Greene, R M

PY - 1985/8/1

Y1 - 1985/8/1

N2 - Treatment of primary cultures of palate mesenchyme cells from AJAX strain embryos with dexamethasone inhibited only phospholipase activity expressed at pH 7.5. A similar treatment did not have such an effect on palate mesenchyme cells from C57BL/6J strain embryos. Since the AJAX strain embryo is sensitive to the induction of cleft palate by exogenous glucocorticoids and the C57BL/6J strain is less so, these data allow consideration of phospholipase activity as a site of regulation for development of the palate.

AB - Treatment of primary cultures of palate mesenchyme cells from AJAX strain embryos with dexamethasone inhibited only phospholipase activity expressed at pH 7.5. A similar treatment did not have such an effect on palate mesenchyme cells from C57BL/6J strain embryos. Since the AJAX strain embryo is sensitive to the induction of cleft palate by exogenous glucocorticoids and the C57BL/6J strain is less so, these data allow consideration of phospholipase activity as a site of regulation for development of the palate.

KW - Animals

KW - Cells

KW - Cultured

KW - Dexamethasone

KW - Hydrogen-Ion Concentration

KW - Inbred Strains

KW - Mice

KW - Palate

KW - Phospholipases

UR - https://digitalcommons.pcom.edu/scholarly_papers/1780

M3 - Article

VL - 32

JO - Teratology

JF - Teratology

ER -

Effects of dexamethasone on phospholipase activities in palate mesenchyme cells in vitro.

Abstract

Keywords

Disciplines

Other files and links

Cite this