Elevation in analgetic effect and plasma levels of morphine by desipramine in rats

Frederick J. Goldstein; P. Mojaverian; M. Ossipov; B. N. Swanson

Elevation in analgetic effect and plasma levels of morphine by desipramine in rats

Frederick J. Goldstein, P. Mojaverian, M. Ossipov, B. N. Swanson

Department of Bio-Medical Sciences (PCOM)

Research output: Contribution to journal › Article › peer-review

Abstract

Pretreatment of rats with desipramine (30 mg/kg, s.c.) enhanced both peak intensity and duration of morphine sulfate (5 mg/kg s.c.) analgesia as determined by measurement of tail flick latency. Morphine concentrations in plasma were also significantly elevated after desipramine. Increased narcotic analgetic responses following desipramine pretreatment appear related to higher circulating levels of unmetabolized morphine. Â© 1982.

Original language	American English
Journal	Pain
Volume	14
State	Published - Jan 1 1982

Keywords

Animal
Drug Synergism
Inbred Strains
Male
Nociceptors
Rats
Sensory Thresholds
animal experiment
desipramine
drug blood level
drug interaction
drug metabolism
drug potentiation
morphine
nociception
nonhuman
peripheral nervous system
pharmacokinetics
rat
subcutaneous drug administration
tail flick test

Disciplines

Medicine and Health Sciences

Cite this

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title = "Elevation in analgetic effect and plasma levels of morphine by desipramine in rats",

abstract = " Pretreatment of rats with desipramine (30 mg/kg, s.c.) enhanced both peak intensity and duration of morphine sulfate (5 mg/kg s.c.) analgesia as determined by measurement of tail flick latency. Morphine concentrations in plasma were also significantly elevated after desipramine. Increased narcotic analgetic responses following desipramine pretreatment appear related to higher circulating levels of unmetabolized morphine. {\^A}{\textcopyright} 1982.",

keywords = "Animal, Drug Synergism, Inbred Strains, Male, Nociceptors, Rats, Sensory Thresholds, animal experiment, desipramine, drug blood level, drug interaction, drug metabolism, drug potentiation, morphine, nociception, nonhuman, peripheral nervous system, pharmacokinetics, rat, subcutaneous drug administration, tail flick test",

author = "Goldstein, {Frederick J.} and P. Mojaverian and M. Ossipov and Swanson, {B. N.}",

year = "1982",

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T1 - Elevation in analgetic effect and plasma levels of morphine by desipramine in rats

AU - Goldstein, Frederick J.

AU - Mojaverian, P.

AU - Ossipov, M.

AU - Swanson, B. N.

PY - 1982/1/1

Y1 - 1982/1/1

N2 - Pretreatment of rats with desipramine (30 mg/kg, s.c.) enhanced both peak intensity and duration of morphine sulfate (5 mg/kg s.c.) analgesia as determined by measurement of tail flick latency. Morphine concentrations in plasma were also significantly elevated after desipramine. Increased narcotic analgetic responses following desipramine pretreatment appear related to higher circulating levels of unmetabolized morphine. Â© 1982.

AB - Pretreatment of rats with desipramine (30 mg/kg, s.c.) enhanced both peak intensity and duration of morphine sulfate (5 mg/kg s.c.) analgesia as determined by measurement of tail flick latency. Morphine concentrations in plasma were also significantly elevated after desipramine. Increased narcotic analgetic responses following desipramine pretreatment appear related to higher circulating levels of unmetabolized morphine. Â© 1982.

KW - Animal

KW - Drug Synergism

KW - Inbred Strains

KW - Male

KW - Nociceptors

KW - Rats

KW - Sensory Thresholds

KW - animal experiment

KW - desipramine

KW - drug blood level

KW - drug interaction

KW - drug metabolism

KW - drug potentiation

KW - morphine

KW - nociception

KW - nonhuman

KW - peripheral nervous system

KW - pharmacokinetics

KW - rat

KW - subcutaneous drug administration

KW - tail flick test

UR - https://digitalcommons.pcom.edu/scholarly_papers/1324

M3 - Article

VL - 14

JO - Pain

JF - Pain

ER -

Elevation in analgetic effect and plasma levels of morphine by desipramine in rats

Abstract

Keywords

Disciplines

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Cite this