Abstract
Using a cat tail-flick analgetic testing procedure, enhancement of the antinociceptive action of morphine (0.25 mg/kg s.c.) was detected following pre-treatment (1 hour) with 10 mg/kg s.c. of either amitriptyline or nortriptyline. No analgesia was observed following s.c. administration of either antidepressant or saline alone. Both central (amine re-uptake blockade; anticholinergic) and peripheral (decreased hepatic biotransformation) actions of tricyclic antidepressants may have contributed to augmentation of morphine analgesia. © 1979.
| Original language | American English |
|---|---|
| Journal | Neuropharmacology |
| Volume | 18 |
| State | Published - Jan 1 1979 |
Keywords
- Animal
- Antidepressive Agents
- Cats
- Drug Synergism
- Male
- Reaction Time
- Time Factors
- Tricyclic
- amitriptyline
- analgesia
- animal experiment
- cat
- drug comparison
- drug potentiation
- morphine
- nervous system
- nortriptyline
- preliminary communication
- subcutaneous drug administration
Disciplines
- Medicine and Health Sciences