Evidence for benzodiazepine receptor interaction with MK 801 in anxiety related behaviour in rats

Avadesh C. Sharma; S. K. Kulkarni

Evidence for benzodiazepine receptor interaction with MK 801 in anxiety related behaviour in rats

Department of Pharmaceutical Sciences

Research output: Contribution to journal › Article › peer-review

Abstract

Antianxiety effect of noncompetitive NMDA receptor antagonist MK 801 was investigated on elevated plus-maze paradigm in rats. Interactional effects of MK 801 with the specific anxiolytic agent, diazepam; the anxiogenic Î²- carboline agent, FG-7142 and the central BZ receptor antagonist Ro 15-1788 were explored. MK 801 (0.025-0.1 mg/kg) produced anxiolytic effect at all the doses in rats. Effect was potentiated by diazepam in rats. Both, FG-7142 and Ro 15-1788 reversed the effects of MK 801 and diazepam, when these agents were concomitantly administered. The study revealed anxiolytic profile of MK 801 and indicates that NMDA receptors can modulate the benzodiazepine receptor activity in rodents in elevated plus-maze apparatus.

Original language	American English
Journal	Indian journal of experimental biology
Volume	31
State	Published - Jan 1 1993

Keywords

Animal
Dizocilpine Maleate
GABA-A
N-Methyl-D-Aspartate
Rats
Receptors
Sprague-Dawley
animal experiment
anxiety
article
behavior
benzodiazepine receptor
controlled study
diazepam
dizocilpine
flumazenil
n methyl beta carboline 3 carboxamide
n methyl dextro aspartic acid receptor
nonhuman
rat

Disciplines

Medicine and Health Sciences

Cite this

@article{6f24932304884acb8d51b0fe9d10b1ee,

title = "Evidence for benzodiazepine receptor interaction with MK 801 in anxiety related behaviour in rats",

abstract = " Antianxiety effect of noncompetitive NMDA receptor antagonist MK 801 was investigated on elevated plus-maze paradigm in rats. Interactional effects of MK 801 with the specific anxiolytic agent, diazepam; the anxiogenic {\^I}²- carboline agent, FG-7142 and the central BZ receptor antagonist Ro 15-1788 were explored. MK 801 (0.025-0.1 mg/kg) produced anxiolytic effect at all the doses in rats. Effect was potentiated by diazepam in rats. Both, FG-7142 and Ro 15-1788 reversed the effects of MK 801 and diazepam, when these agents were concomitantly administered. The study revealed anxiolytic profile of MK 801 and indicates that NMDA receptors can modulate the benzodiazepine receptor activity in rodents in elevated plus-maze apparatus.",

keywords = "Animal, Dizocilpine Maleate, GABA-A, N-Methyl-D-Aspartate, Rats, Receptors, Sprague-Dawley, animal experiment, anxiety, article, behavior, benzodiazepine receptor, controlled study, diazepam, dizocilpine, flumazenil, n methyl beta carboline 3 carboxamide, n methyl dextro aspartic acid receptor, nonhuman, rat",

author = "Sharma, {Avadesh C.} and Kulkarni, {S. K.}",

year = "1993",

month = jan,

day = "1",

language = "American English",

volume = "31",

journal = "Indian journal of experimental biology",

}

TY - JOUR

T1 - Evidence for benzodiazepine receptor interaction with MK 801 in anxiety related behaviour in rats

AU - Sharma, Avadesh C.

AU - Kulkarni, S. K.

PY - 1993/1/1

Y1 - 1993/1/1

N2 - Antianxiety effect of noncompetitive NMDA receptor antagonist MK 801 was investigated on elevated plus-maze paradigm in rats. Interactional effects of MK 801 with the specific anxiolytic agent, diazepam; the anxiogenic Î²- carboline agent, FG-7142 and the central BZ receptor antagonist Ro 15-1788 were explored. MK 801 (0.025-0.1 mg/kg) produced anxiolytic effect at all the doses in rats. Effect was potentiated by diazepam in rats. Both, FG-7142 and Ro 15-1788 reversed the effects of MK 801 and diazepam, when these agents were concomitantly administered. The study revealed anxiolytic profile of MK 801 and indicates that NMDA receptors can modulate the benzodiazepine receptor activity in rodents in elevated plus-maze apparatus.

AB - Antianxiety effect of noncompetitive NMDA receptor antagonist MK 801 was investigated on elevated plus-maze paradigm in rats. Interactional effects of MK 801 with the specific anxiolytic agent, diazepam; the anxiogenic Î²- carboline agent, FG-7142 and the central BZ receptor antagonist Ro 15-1788 were explored. MK 801 (0.025-0.1 mg/kg) produced anxiolytic effect at all the doses in rats. Effect was potentiated by diazepam in rats. Both, FG-7142 and Ro 15-1788 reversed the effects of MK 801 and diazepam, when these agents were concomitantly administered. The study revealed anxiolytic profile of MK 801 and indicates that NMDA receptors can modulate the benzodiazepine receptor activity in rodents in elevated plus-maze apparatus.

KW - Animal

KW - Dizocilpine Maleate

KW - GABA-A

KW - N-Methyl-D-Aspartate

KW - Rats

KW - Receptors

KW - Sprague-Dawley

KW - animal experiment

KW - anxiety

KW - article

KW - behavior

KW - benzodiazepine receptor

KW - controlled study

KW - diazepam

KW - dizocilpine

KW - flumazenil

KW - n methyl beta carboline 3 carboxamide

KW - n methyl dextro aspartic acid receptor

KW - nonhuman

KW - rat

UR - https://digitalcommons.pcom.edu/scholarly_papers/983

M3 - Article

VL - 31

JO - Indian journal of experimental biology

JF - Indian journal of experimental biology

ER -

Evidence for benzodiazepine receptor interaction with MK 801 in anxiety related behaviour in rats

Abstract

Keywords

Disciplines

Other files and links

Cite this