Functional Roles of IMP Isoforms in Axon Regeneration by Localizing Specific mRNAs

Functional Roles of IMP Isoforms in Axon Regeneration by Localizing Specific mRNAs – Axon degeneration is a common pathway leading to neurological deficits after spinal cord and nerve injuries. However, therapeutic approaches to enhance axon regeneration are very limited. Our recent studies point to the functional importance of localizing mRNAs into neuronal axons and subsequently translating them into proteins. The purpose of this project is to investigate molecular mechanisms underlying axon regeneration. We will focus on insulin-like growth factor-II mRNA-binding protein (IMP) isoforms which are known to localize specific mRNAs into regenerating axon. This study will advance our knowledge of the regenerative process and lead to effective therapeutic strategies for axon regeneration.