Functionalized surfaces for bone cell adhesion

P. Ducheyne; G. Toworfe; M. H. Lee; R. J. Composto; Christopher S. Adams; I. M. Shapiro

Functionalized surfaces for bone cell adhesion

P. Ducheyne, G. Toworfe, M. H. Lee, R. J. Composto, Christopher S. Adams, I. M. Shapiro

Department of Bio-Medical Sciences (PCOM)

Research output: Contribution to journal › Article › peer-review

Abstract

The approaches used for bone repair problems encountered in fracture treatment, joint replacement revision surgery and spinal fusion procedures including utilization of autografts, allografts and synthetic grafts were described. The scaffolds with grafted biological groups and both cellular adhesion and osteogenic cell differentiation were also analyzed. The adhesion of K 100 cells to 3-aminopropyltriethoxysilane (APTES) and RGD on APTES were determined to examine the roles of non-specific and specific forces on Î±vÎ²3 integrin-mediated cell adhesion. The biomaterials designed with positively-charged surfaces could amplify the effectiveness of tethered RGD peptides to stimulate cell activity.

Original language	American English
Journal	Transactions - 7th World Biomaterials Congress
State	Published - Jan 1 2004

Keywords

Adhesion
Adsorption
Biomaterials
Bone
Cell adhesion
Cell culture
Differentiation (calculus)
Fluorescence
Fusion reactions
Grafts
Hydrophobicity
Monolayers
Osteoblasts
Self assembly
Synthetic grafts
Tissue engineering
pH effects

Disciplines

Life Sciences

Cite this

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title = "Functionalized surfaces for bone cell adhesion",

abstract = " The approaches used for bone repair problems encountered in fracture treatment, joint replacement revision surgery and spinal fusion procedures including utilization of autografts, allografts and synthetic grafts were described. The scaffolds with grafted biological groups and both cellular adhesion and osteogenic cell differentiation were also analyzed. The adhesion of K 100 cells to 3-aminopropyltriethoxysilane (APTES) and RGD on APTES were determined to examine the roles of non-specific and specific forces on {\^I}±v{\^I}²3 integrin-mediated cell adhesion. The biomaterials designed with positively-charged surfaces could amplify the effectiveness of tethered RGD peptides to stimulate cell activity.",

keywords = "Adhesion, Adsorption, Biomaterials, Bone, Cell adhesion, Cell culture, Differentiation (calculus), Fluorescence, Fusion reactions, Grafts, Hydrophobicity, Monolayers, Osteoblasts, Self assembly, Synthetic grafts, Tissue engineering, pH effects",

author = "P. Ducheyne and G. Toworfe and Lee, {M. H.} and Composto, {R. J.} and Adams, {Christopher S.} and Shapiro, {I. M.}",

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language = "American English",

journal = "Transactions - 7th World Biomaterials Congress",

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TY - JOUR

T1 - Functionalized surfaces for bone cell adhesion

AU - Ducheyne, P.

AU - Toworfe, G.

AU - Lee, M. H.

AU - Composto, R. J.

AU - Adams, Christopher S.

AU - Shapiro, I. M.

PY - 2004/1/1

Y1 - 2004/1/1

N2 - The approaches used for bone repair problems encountered in fracture treatment, joint replacement revision surgery and spinal fusion procedures including utilization of autografts, allografts and synthetic grafts were described. The scaffolds with grafted biological groups and both cellular adhesion and osteogenic cell differentiation were also analyzed. The adhesion of K 100 cells to 3-aminopropyltriethoxysilane (APTES) and RGD on APTES were determined to examine the roles of non-specific and specific forces on Î±vÎ²3 integrin-mediated cell adhesion. The biomaterials designed with positively-charged surfaces could amplify the effectiveness of tethered RGD peptides to stimulate cell activity.

AB - The approaches used for bone repair problems encountered in fracture treatment, joint replacement revision surgery and spinal fusion procedures including utilization of autografts, allografts and synthetic grafts were described. The scaffolds with grafted biological groups and both cellular adhesion and osteogenic cell differentiation were also analyzed. The adhesion of K 100 cells to 3-aminopropyltriethoxysilane (APTES) and RGD on APTES were determined to examine the roles of non-specific and specific forces on Î±vÎ²3 integrin-mediated cell adhesion. The biomaterials designed with positively-charged surfaces could amplify the effectiveness of tethered RGD peptides to stimulate cell activity.

KW - Adhesion

KW - Adsorption

KW - Biomaterials

KW - Bone

KW - Cell adhesion

KW - Cell culture

KW - Differentiation (calculus)

KW - Fluorescence

KW - Fusion reactions

KW - Grafts

KW - Hydrophobicity

KW - Monolayers

KW - Osteoblasts

KW - Self assembly

KW - Synthetic grafts

KW - Tissue engineering

KW - pH effects

UR - https://digitalcommons.pcom.edu/scholarly_papers/1560

M3 - Article

JO - Transactions - 7th World Biomaterials Congress

JF - Transactions - 7th World Biomaterials Congress

ER -

Functionalized surfaces for bone cell adhesion

Abstract

Keywords

Disciplines

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