Germline Mutations in Patients With Early-Onset Prostate Cancer.

Tang Tang; Xintao Tan; Ze Wang; Shuo Wang; Yapeng Wang; Jing Xu; Xiajie Wei; Dianzheng Zhang; Qiuli Liu; Jun Jiang

Germline Mutations in Patients With Early-Onset Prostate Cancer.

Tang Tang, Xintao Tan, Ze Wang, Shuo Wang, Yapeng Wang, Jing Xu, Xiajie Wei, Dianzheng Zhang, Qiuli Liu, Jun Jiang

Department of Bio-Medical Sciences (PCOM)

Research output: Contribution to journal › Article › peer-review

Abstract

Objective: To investigate the inherited mutations and their association with clinical features and treatment response in young-onset prostate cancer patients.

Method: Targeted gene sequencing on 139 tumor susceptibility genes was conducted with a total of 24 patients diagnosed with PCa under the age of 63 years old. Meanwhile, the related clinical information of those patients is collected and analyzed.

Results: Sixty-two germline mutations in 45 genes were verified in 22 patients.

Conclusion: Mutations in DRGs are more prevalent in early-onset PCa with advanced clinical stages, and these patients had shorter progression-free survival. ADT Combined with either radiotherapy or chemotherapy may be effective in treating PCa caused by HRR-related gene mutations.

Original language	American English
Journal	Frontiers in Oncology
Volume	12
State	Published - Jan 1 2022

Keywords

early-onset
germline mutations
homologous recombination associated genes
next-generation sequencing
prostate cancer

Disciplines

Medicine and Health Sciences

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Germline Mutations in Patients With Early-Onset Prostate CancerFinal published version, 1.79 MBLicense: CC BY

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title = "Germline Mutations in Patients With Early-Onset Prostate Cancer.",

abstract = " Objective: To investigate the inherited mutations and their association with clinical features and treatment response in young-onset prostate cancer patients. Method: Targeted gene sequencing on 139 tumor susceptibility genes was conducted with a total of 24 patients diagnosed with PCa under the age of 63 years old. Meanwhile, the related clinical information of those patients is collected and analyzed. Results: Sixty-two germline mutations in 45 genes were verified in 22 patients. Conclusion: Mutations in DRGs are more prevalent in early-onset PCa with advanced clinical stages, and these patients had shorter progression-free survival. ADT Combined with either radiotherapy or chemotherapy may be effective in treating PCa caused by HRR-related gene mutations.",

keywords = "early-onset, germline mutations, homologous recombination associated genes, next-generation sequencing, prostate cancer",

author = "Tang Tang and Xintao Tan and Ze Wang and Shuo Wang and Yapeng Wang and Jing Xu and Xiajie Wei and Dianzheng Zhang and Qiuli Liu and Jun Jiang",

year = "2022",

month = jan,

day = "1",

language = "American English",

volume = "12",

journal = "Frontiers in Oncology",

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TY - JOUR

T1 - Germline Mutations in Patients With Early-Onset Prostate Cancer.

AU - Tang, Tang

AU - Tan, Xintao

AU - Wang, Ze

AU - Wang, Shuo

AU - Wang, Yapeng

AU - Xu, Jing

AU - Wei, Xiajie

AU - Zhang, Dianzheng

AU - Liu, Qiuli

AU - Jiang, Jun

PY - 2022/1/1

Y1 - 2022/1/1

N2 - Objective: To investigate the inherited mutations and their association with clinical features and treatment response in young-onset prostate cancer patients. Method: Targeted gene sequencing on 139 tumor susceptibility genes was conducted with a total of 24 patients diagnosed with PCa under the age of 63 years old. Meanwhile, the related clinical information of those patients is collected and analyzed. Results: Sixty-two germline mutations in 45 genes were verified in 22 patients. Conclusion: Mutations in DRGs are more prevalent in early-onset PCa with advanced clinical stages, and these patients had shorter progression-free survival. ADT Combined with either radiotherapy or chemotherapy may be effective in treating PCa caused by HRR-related gene mutations.

AB - Objective: To investigate the inherited mutations and their association with clinical features and treatment response in young-onset prostate cancer patients. Method: Targeted gene sequencing on 139 tumor susceptibility genes was conducted with a total of 24 patients diagnosed with PCa under the age of 63 years old. Meanwhile, the related clinical information of those patients is collected and analyzed. Results: Sixty-two germline mutations in 45 genes were verified in 22 patients. Conclusion: Mutations in DRGs are more prevalent in early-onset PCa with advanced clinical stages, and these patients had shorter progression-free survival. ADT Combined with either radiotherapy or chemotherapy may be effective in treating PCa caused by HRR-related gene mutations.

KW - early-onset

KW - germline mutations

KW - homologous recombination associated genes

KW - next-generation sequencing

KW - prostate cancer

UR - https://digitalcommons.pcom.edu/scholarly_papers/2161

M3 - Article

VL - 12

JO - Frontiers in Oncology

JF - Frontiers in Oncology

ER -

Germline Mutations in Patients With Early-Onset Prostate Cancer.

Abstract

Keywords

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