In vitro sensitivity of cholinesterases and [3H]oxotremorine-M binding in heart and brain of adult and aging rats to organophosphorus anticholinesterases

Nikita Mirajkar; Carey N. Pope

doi:10.1016/j.bcp.2008.08.001

In vitro sensitivity of cholinesterases and [3H]oxotremorine-M binding in heart and brain of adult and aging rats to organophosphorus anticholinesterases

Nikita Mirajkar
, Carey N. Pope

Department of Bio-Medical Sciences (PCOM)

Research output: Contribution to journal › Article › peer-review

Original language	American English
Journal	Biochemical Pharmacology
Volume	76
DOIs	https://doi.org/10.1016/j.bcp.2008.08.001
State	Published - Oct 1 2008

Disciplines

Biochemistry
Internal Medicine
Endocrinology

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10.1016/j.bcp.2008.08.001License: Unspecified

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@article{264cabe00b094656b7bbf2c5e1cb8c7a,

title = "In vitro sensitivity of cholinesterases and [3H]oxotremorine-M binding in heart and brain of adult and aging rats to organophosphorus anticholinesterases",

author = "Nikita Mirajkar and Pope, \{Carey N.\}",

note = "Organophosphorus (OP) insecticides elicit toxicity via acetylcholinesterase inhibition, allowing acetylcholine accumulation and excessive stimulation of cholinergic receptors. Some OP insecticides bind to additional macromolecules including butyrylcholinesterase and cholinergic receptors. While neurotoxicity from OP anticholinesterases has been extensively studied, effects on cardiac function have received less attention.",

year = "2008",

month = oct,

day = "1",

doi = "10.1016/j.bcp.2008.08.001",

language = "American English",

volume = "76",

journal = "Biochemical Pharmacology",

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TY - JOUR

T1 - In vitro sensitivity of cholinesterases and [3H]oxotremorine-M binding in heart and brain of adult and aging rats to organophosphorus anticholinesterases

AU - Mirajkar, Nikita

AU - Pope, Carey N.

N1 - Organophosphorus (OP) insecticides elicit toxicity via acetylcholinesterase inhibition, allowing acetylcholine accumulation and excessive stimulation of cholinergic receptors. Some OP insecticides bind to additional macromolecules including butyrylcholinesterase and cholinergic receptors. While neurotoxicity from OP anticholinesterases has been extensively studied, effects on cardiac function have received less attention.

PY - 2008/10/1

Y1 - 2008/10/1

UR - http://europepmc.org/articles/PMC2572567

U2 - 10.1016/j.bcp.2008.08.001

DO - 10.1016/j.bcp.2008.08.001

M3 - Article

VL - 76

JO - Biochemical Pharmacology

JF - Biochemical Pharmacology

ER -

In vitro sensitivity of cholinesterases and [3H]oxotremorine-M binding in heart and brain of adult and aging rats to organophosphorus anticholinesterases

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