Involvement of matrix metalloproteinase 2 and 9 in gambogic acid induced suppression of MDA-MB-435 human breast carcinoma cell lung metastasis

TY - JOUR

T1 - Involvement of matrix metalloproteinase 2 and 9 in gambogic acid induced suppression of MDA-MB-435 human breast carcinoma cell lung metastasis

AU - Qi, Qi

AU - Gu, Hongyan

AU - Yang, Yong

AU - Lu, Na

AU - Zhao, Jie

AU - Liu, Wei

AU - Ling, Hua

AU - You, Qi-dong

AU - Wang, Xiaotang

AU - Guo, Qinglong

N1 - Cancer cell invasion is one of the crucial events in local spreading, growth, and metastasis of tumors. The present study investigated the antiinvasive and antimetastatic action of gambogic acid (GA) in MDA-MB-435 human breast carcinoma cells. GA caused a concentration-dependent suppression of cell invasion through Matrigel and significantly inhibited lung metastases of the cells transplanted in vivo.

PY - 2008/12/1

Y1 - 2008/12/1

UR - https://link.springer.com/content/pdf/10.1007%2Fs00109-008-0398-z.pdf

U2 - 10.1007/s00109-008-0398-z

DO - 10.1007/s00109-008-0398-z

M3 - Article

VL - 86

JO - Journal of Molecular Medicine

JF - Journal of Molecular Medicine

ER -