@article{30d079399b1c4bce8a3e1e4ef43e9a1d,
title = "ISOPRENOID-MEDIATED INHIBITION OF MEVALONATE SYNTHESIS : POTENTIAL APPLICATION TO CANCER",
author = "Elson, {Charles E.} and Peffley, {Dennis M.} and Patricia Hentosh and Huanbiao Mo",
note = "Abstract Pure and mixed isoprenoid end products of plant mevalonate metabolism trigger actions that suppress 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase activity. These actions modulate HMG CoA reductase mRNA translation and the proteolytic degradation of HMG CoA reductase. Such post-transcriptional events, we propose, are activated directly by acyclic isoprenoids and indirectly by cyclic isoprenoids.",
year = "1999",
month = jan,
day = "8",
doi = "10.1046/j.1525-1373.1999.d01-87.x",
language = "American English",
volume = "221",
journal = "Experimental Biology and Medicine",
}