ISOPRENOID-MEDIATED INHIBITION OF MEVALONATE SYNTHESIS : POTENTIAL APPLICATION TO CANCER

Charles E. Elson; Dennis M. Peffley; Patricia Hentosh; Huanbiao Mo

doi:10.1046/j.1525-1373.1999.d01-87.x

ISOPRENOID-MEDIATED INHIBITION OF MEVALONATE SYNTHESIS : POTENTIAL APPLICATION TO CANCER

Charles E. Elson
, Dennis M. Peffley
, Patricia Hentosh
, Huanbiao Mo

Department of Bio-Medical Sciences (PCOM)

Research output: Contribution to journal › Article › peer-review

Original language	American English
Journal	Experimental Biology and Medicine
Volume	221
DOIs	https://doi.org/10.1046/j.1525-1373.1999.d01-87.x
State	Published - Jan 8 1999

Disciplines

Biochemistry
Biology

Access to Document

10.1046/j.1525-1373.1999.d01-87.xLicense: Unspecified

Cite this

@article{30d079399b1c4bce8a3e1e4ef43e9a1d,

title = "ISOPRENOID-MEDIATED INHIBITION OF MEVALONATE SYNTHESIS : POTENTIAL APPLICATION TO CANCER",

author = "Elson, \{Charles E.\} and Peffley, \{Dennis M.\} and Patricia Hentosh and Huanbiao Mo",

note = "Abstract Pure and mixed isoprenoid end products of plant mevalonate metabolism trigger actions that suppress 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase activity. These actions modulate HMG CoA reductase mRNA translation and the proteolytic degradation of HMG CoA reductase. Such post-transcriptional events, we propose, are activated directly by acyclic isoprenoids and indirectly by cyclic isoprenoids.",

year = "1999",

month = jan,

day = "8",

doi = "10.1046/j.1525-1373.1999.d01-87.x",

language = "American English",

volume = "221",

journal = "Experimental Biology and Medicine",

}

TY - JOUR

T1 - ISOPRENOID-MEDIATED INHIBITION OF MEVALONATE SYNTHESIS : POTENTIAL APPLICATION TO CANCER

AU - Elson, Charles E.

AU - Peffley, Dennis M.

AU - Hentosh, Patricia

AU - Mo, Huanbiao

N1 - Abstract Pure and mixed isoprenoid end products of plant mevalonate metabolism trigger actions that suppress 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase activity. These actions modulate HMG CoA reductase mRNA translation and the proteolytic degradation of HMG CoA reductase. Such post-transcriptional events, we propose, are activated directly by acyclic isoprenoids and indirectly by cyclic isoprenoids.

PY - 1999/1/8

Y1 - 1999/1/8

UR - http://journals.sagepub.com/doi/abs/10.3181/00379727-221-44413

U2 - 10.1046/j.1525-1373.1999.d01-87.x

DO - 10.1046/j.1525-1373.1999.d01-87.x

M3 - Article

VL - 221

JO - Experimental Biology and Medicine

JF - Experimental Biology and Medicine

ER -

ISOPRENOID-MEDIATED INHIBITION OF MEVALONATE SYNTHESIS : POTENTIAL APPLICATION TO CANCER

Disciplines

Access to Document

Other files and links

Cite this