Mapping of the mouse fibronectin gene (Fn-1) to chromosome 1: conservation of the Idh-1-Cryg-Fn-1 synteny group in mammals

L C Skow; L Adkison; J E Womack; W G Beamer; B A Taylor

doi:10.1016/0888-7543(87)90057-7

Mapping of the mouse fibronectin gene (Fn-1) to chromosome 1: conservation of the Idh-1-Cryg-Fn-1 synteny group in mammals

L C Skow, L Adkison, J E Womack, W G Beamer, B A Taylor

Department of Bio-Medical Sciences (PCOM Georgia)

Research output: Contribution to journal › Article › peer-review

Abstract

Restriction fragment length polymorphisms (RFLPs) were observed in BamHI-digested mouse DNA probed with a cDNA for human fibronectin. Analysis of the inheritance of fibronectin RFLPs in AKXD and SWXJ recombinant inbred strains of mice mapped the locus, Fn-1, to the midregion of mouse chromosome 1 about 4 cM distal from the loci encoding gamma-crystallins (Cryg). Loci homologous to genes in the centromeric third of mouse chromosome 1 are also syntenic in rats, humans, and cattle and may, therefore, mark a large conserved chromosomal segment of the mammalian genome.

Original language	English
Pages (from-to)	283-6
Number of pages	4
Journal	Genomics
Volume	1
Issue number	3
DOIs	https://doi.org/10.1016/0888-7543(87)90057-7
State	Published - Oct 1987

Keywords

Animals
Biological Evolution
Chromosome Mapping
Crystallins/genetics
Fibronectins/genetics
Genetic Linkage
Humans
Isocitrate Dehydrogenase/genetics
Mammals/genetics
Mice
Mice, Inbred Strains
Polymorphism, Restriction Fragment Length

Access to Document

10.1016/0888-7543(87)90057-7

Cite this

@article{f900bf4e46714dfdbaa384059ff76f57,

title = "Mapping of the mouse fibronectin gene (Fn-1) to chromosome 1: conservation of the Idh-1-Cryg-Fn-1 synteny group in mammals",

abstract = "Restriction fragment length polymorphisms (RFLPs) were observed in BamHI-digested mouse DNA probed with a cDNA for human fibronectin. Analysis of the inheritance of fibronectin RFLPs in AKXD and SWXJ recombinant inbred strains of mice mapped the locus, Fn-1, to the midregion of mouse chromosome 1 about 4 cM distal from the loci encoding gamma-crystallins (Cryg). Loci homologous to genes in the centromeric third of mouse chromosome 1 are also syntenic in rats, humans, and cattle and may, therefore, mark a large conserved chromosomal segment of the mammalian genome.",

keywords = "Animals, Biological Evolution, Chromosome Mapping, Crystallins/genetics, Fibronectins/genetics, Genetic Linkage, Humans, Isocitrate Dehydrogenase/genetics, Mammals/genetics, Mice, Mice, Inbred Strains, Polymorphism, Restriction Fragment Length",

author = "Skow, {L C} and L Adkison and Womack, {J E} and Beamer, {W G} and Taylor, {B A}",

year = "1987",

month = oct,

doi = "10.1016/0888-7543(87)90057-7",

language = "English",

volume = "1",

pages = "283--6",

journal = "Genomics",

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TY - JOUR

T1 - Mapping of the mouse fibronectin gene (Fn-1) to chromosome 1

T2 - conservation of the Idh-1-Cryg-Fn-1 synteny group in mammals

AU - Skow, L C

AU - Adkison, L

AU - Womack, J E

AU - Beamer, W G

AU - Taylor, B A

PY - 1987/10

Y1 - 1987/10

N2 - Restriction fragment length polymorphisms (RFLPs) were observed in BamHI-digested mouse DNA probed with a cDNA for human fibronectin. Analysis of the inheritance of fibronectin RFLPs in AKXD and SWXJ recombinant inbred strains of mice mapped the locus, Fn-1, to the midregion of mouse chromosome 1 about 4 cM distal from the loci encoding gamma-crystallins (Cryg). Loci homologous to genes in the centromeric third of mouse chromosome 1 are also syntenic in rats, humans, and cattle and may, therefore, mark a large conserved chromosomal segment of the mammalian genome.

AB - Restriction fragment length polymorphisms (RFLPs) were observed in BamHI-digested mouse DNA probed with a cDNA for human fibronectin. Analysis of the inheritance of fibronectin RFLPs in AKXD and SWXJ recombinant inbred strains of mice mapped the locus, Fn-1, to the midregion of mouse chromosome 1 about 4 cM distal from the loci encoding gamma-crystallins (Cryg). Loci homologous to genes in the centromeric third of mouse chromosome 1 are also syntenic in rats, humans, and cattle and may, therefore, mark a large conserved chromosomal segment of the mammalian genome.

KW - Animals

KW - Biological Evolution

KW - Chromosome Mapping

KW - Crystallins/genetics

KW - Fibronectins/genetics

KW - Genetic Linkage

KW - Humans

KW - Isocitrate Dehydrogenase/genetics

KW - Mammals/genetics

KW - Mice

KW - Mice, Inbred Strains

KW - Polymorphism, Restriction Fragment Length

U2 - 10.1016/0888-7543(87)90057-7

DO - 10.1016/0888-7543(87)90057-7

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JO - Genomics

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