Microbes and Alzheimer's Disease

Ruth Itzhaki; Richard Lathe; Brian J. Balin; Melvyn J. Ball; Elaine L. Bearer; et al.

doi:10.3233/JAD-160152

Microbes and Alzheimer's Disease

Ruth Itzhaki, Richard Lathe, Brian J. Balin, Melvyn J. Ball, Elaine L. Bearer, et al.

Research output: Contribution to journal › Article › peer-review

Abstract

 We are researchers and clinicians working on
 Alzheimer’s disease (AD) or related topics, and we
 write to express our concern that one particular aspect
 of the disease has been neglected, even though treatment
 based on it might slow or arrest AD progression.
 We refer to the many studies, mainly on humans,
 implicating specific microbes in the elderly brain,
 notably herpes simplex virus type 1 (HSV1),Chlamydia
 pneumoniae, and several types of spirochaete, in
 the etiology of AD. Fungal infection of AD
 brain has also been described, as well as abnormal
 microbiota in AD patient blood. The first
 observations of HSV1 in AD brain were reported
 almost three decades ago. The ever-increasing
 number of these studies (now about 100 on HSV1
 alone) warrants re-evaluation of the infection and AD
 concept.

Original language	American English
Journal	Journal of Alzheimer's Disease
Volume	51
DOIs	https://doi.org/10.3233/JAD-160152
State	Published - Apr 2016

Keywords

Chlamydia pneumonia
alzheimer's Disease
infectious disease

Disciplines

Life Sciences

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Cite this

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title = "Microbes and Alzheimer's Disease",

abstract = " We are researchers and clinicians working on Alzheimer{\textquoteright}s disease (AD) or related topics, and we write to express our concern that one particular aspect of the disease has been neglected, even though treatment based on it might slow or arrest AD progression. We refer to the many studies, mainly on humans, implicating specific microbes in the elderly brain, notably herpes simplex virus type 1 (HSV1),Chlamydia pneumoniae, and several types of spirochaete, in the etiology of AD. Fungal infection of AD brain has also been described, as well as abnormal microbiota in AD patient blood. The first observations of HSV1 in AD brain were reported almost three decades ago. The ever-increasing number of these studies (now about 100 on HSV1 alone) warrants re-evaluation of the infection and AD concept.",

keywords = "Chlamydia pneumonia, alzheimer's Disease, infectious disease",

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AU - Itzhaki, Ruth

AU - Lathe, Richard

AU - Balin, Brian J.

AU - Ball, Melvyn J.

AU - Bearer, Elaine L.

AU - al., et

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N2 - We are researchers and clinicians working on Alzheimer’s disease (AD) or related topics, and we write to express our concern that one particular aspect of the disease has been neglected, even though treatment based on it might slow or arrest AD progression. We refer to the many studies, mainly on humans, implicating specific microbes in the elderly brain, notably herpes simplex virus type 1 (HSV1),Chlamydia pneumoniae, and several types of spirochaete, in the etiology of AD. Fungal infection of AD brain has also been described, as well as abnormal microbiota in AD patient blood. The first observations of HSV1 in AD brain were reported almost three decades ago. The ever-increasing number of these studies (now about 100 on HSV1 alone) warrants re-evaluation of the infection and AD concept.

AB - We are researchers and clinicians working on Alzheimer’s disease (AD) or related topics, and we write to express our concern that one particular aspect of the disease has been neglected, even though treatment based on it might slow or arrest AD progression. We refer to the many studies, mainly on humans, implicating specific microbes in the elderly brain, notably herpes simplex virus type 1 (HSV1),Chlamydia pneumoniae, and several types of spirochaete, in the etiology of AD. Fungal infection of AD brain has also been described, as well as abnormal microbiota in AD patient blood. The first observations of HSV1 in AD brain were reported almost three decades ago. The ever-increasing number of these studies (now about 100 on HSV1 alone) warrants re-evaluation of the infection and AD concept.

KW - Chlamydia pneumonia

KW - alzheimer's Disease

KW - infectious disease

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DO - 10.3233/JAD-160152

M3 - Article

VL - 51

JO - Journal of Alzheimer's Disease

JF - Journal of Alzheimer's Disease

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