MTA3 Represses Cancer Stemness by Targeting the SOX2OT/SOX2 Axis

Liang Du; Lu Wang; Jinfeng Gan; Zhimeng Yao; Wan Lin; Junkuo Li; Yi Guo; Yuping Chen; Fuyou Zhou; Sai-Ching Jim Yeung; Robert P Coppes; Dianzheng Zhang; Hao Zhang

MTA3 Represses Cancer Stemness by Targeting the SOX2OT/SOX2 Axis

Liang Du, Lu Wang, Jinfeng Gan, Zhimeng Yao, Wan Lin, Junkuo Li, Yi Guo, Yuping Chen, Fuyou Zhou, Sai-Ching Jim Yeung, Robert P Coppes, Dianzheng Zhang, Hao Zhang

Department of Bio-Medical Sciences (PCOM)

Research output: Contribution to journal › Article › peer-review

Abstract

Cancer cell stemness (CCS) plays critical roles in both malignancy maintenance and metastasis, yet the underlying molecular mechanisms are far from complete. Although the importance of SOX2 in cancer development and CCS are well recognized, the role of MTA3 in these processes is unknown. In this study, we used esophageal squamous cell carcinoma (ESCC) as a model system to demonstrate that MTA3 can repress both CCS and metastasis in vitro and in vivo. Mechanistically, by forming a repressive complex with GATA3, MTA3 downregulates SOX2OT, subsequently suppresses the SOX2OT/SOX2 axis, and ultimately represses CCS and metastasis. More importantly, MTA3

Original language	American English
Journal	iScience
Volume	22
State	Published - Dec 20 2019

Keywords

Biological Sciences
Cancer
Cell Biology
Molecular Biology
Stem Cells Research

Disciplines

Medicine and Health Sciences
Oncology

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MTA3 Represses Cancer Stemness by Targeting the SOX2OT SOX2 AxisFinal published version, 12.3 MBLicense: CC BY

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title = "MTA3 Represses Cancer Stemness by Targeting the SOX2OT/SOX2 Axis",

abstract = " Cancer cell stemness (CCS) plays critical roles in both malignancy maintenance and metastasis, yet the underlying molecular mechanisms are far from complete. Although the importance of SOX2 in cancer development and CCS are well recognized, the role of MTA3 in these processes is unknown. In this study, we used esophageal squamous cell carcinoma (ESCC) as a model system to demonstrate that MTA3 can repress both CCS and metastasis in vitro and in vivo. Mechanistically, by forming a repressive complex with GATA3, MTA3 downregulates SOX2OT, subsequently suppresses the SOX2OT/SOX2 axis, and ultimately represses CCS and metastasis. More importantly, MTA3",

keywords = "Biological Sciences, Cancer, Cell Biology, Molecular Biology, Stem Cells Research",

author = "Liang Du and Lu Wang and Jinfeng Gan and Zhimeng Yao and Wan Lin and Junkuo Li and Yi Guo and Yuping Chen and Fuyou Zhou and {Jim Yeung}, Sai-Ching and Coppes, {Robert P} and Dianzheng Zhang and Hao Zhang",

year = "2019",

month = dec,

day = "20",

language = "American English",

volume = "22",

journal = "iScience",

}

TY - JOUR

T1 - MTA3 Represses Cancer Stemness by Targeting the SOX2OT/SOX2 Axis

AU - Du, Liang

AU - Wang, Lu

AU - Gan, Jinfeng

AU - Yao, Zhimeng

AU - Lin, Wan

AU - Li, Junkuo

AU - Guo, Yi

AU - Chen, Yuping

AU - Zhou, Fuyou

AU - Jim Yeung, Sai-Ching

AU - Coppes, Robert P

AU - Zhang, Dianzheng

AU - Zhang, Hao

PY - 2019/12/20

Y1 - 2019/12/20

N2 - Cancer cell stemness (CCS) plays critical roles in both malignancy maintenance and metastasis, yet the underlying molecular mechanisms are far from complete. Although the importance of SOX2 in cancer development and CCS are well recognized, the role of MTA3 in these processes is unknown. In this study, we used esophageal squamous cell carcinoma (ESCC) as a model system to demonstrate that MTA3 can repress both CCS and metastasis in vitro and in vivo. Mechanistically, by forming a repressive complex with GATA3, MTA3 downregulates SOX2OT, subsequently suppresses the SOX2OT/SOX2 axis, and ultimately represses CCS and metastasis. More importantly, MTA3

AB - Cancer cell stemness (CCS) plays critical roles in both malignancy maintenance and metastasis, yet the underlying molecular mechanisms are far from complete. Although the importance of SOX2 in cancer development and CCS are well recognized, the role of MTA3 in these processes is unknown. In this study, we used esophageal squamous cell carcinoma (ESCC) as a model system to demonstrate that MTA3 can repress both CCS and metastasis in vitro and in vivo. Mechanistically, by forming a repressive complex with GATA3, MTA3 downregulates SOX2OT, subsequently suppresses the SOX2OT/SOX2 axis, and ultimately represses CCS and metastasis. More importantly, MTA3

KW - Biological Sciences

KW - Cancer

KW - Cell Biology

KW - Molecular Biology

KW - Stem Cells Research

UR - https://digitalcommons.pcom.edu/scholarly_papers/2039

M3 - Article

VL - 22

JO - iScience

JF - iScience

ER -

MTA3 Represses Cancer Stemness by Targeting the SOX2OT/SOX2 Axis

Abstract

Keywords

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