Multifacted Role of TNF-α During the Pathogenesis of Rheumatoid Arthritis

Mula Ramanjaneya, Rangaiah Shashidharamurthy, Shashidharamurthy Taval

Research output: Contribution to journalArticlepeer-review

Abstract

Tumor necrosis factor alpha (TNF-α) a cytokine has been shown to be the key player during the pathogenesis of several autoimmune inflammatory disorders (presumably sterile inflammation) including rheumatoid arthritis (RA). Several studies have shown that TNF-α is mainly involved in the proinflammatory responses. However recent studies have reported multifunctional role of TNF-α during the development of RA. Therefore, in this article we have highlighted the distinct functions of TNF-α during pathogenesis of RA

Original languageAmerican English
JournalAdvances in Bioscience and Biotechnology
Volume4
StatePublished - Jan 1 2013

Keywords

  • Cytokines
  • Tumor Necrosis Factor-α
  • Rheumatoid Arthritis
  • Inflammation

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