Abstract
The pharmacokinetic profiles of caffeic acid phenethyl ester (CAPE) and its catechol-ring fluorinated derivative (FCAPE) were determined in rats after intravenous administration of 5, 10 or 20 mg/kg for CAPE and 20 mg/kg for FCAPE, respectively. The plasma concentrations of CAPE and FCAPE were measured using a validated liquid chromatography tandem mass spectrometric method. The pharmacokinetic parameters were estimated using non compartmental analysis (NCA) and biexponential fit. The results showed that the area under the plasma concentration-time curve for CAPE treatment increased in a proportion greater than the increase in dose from 5 to 20 mg/kg of CAPE. Total body clearance values for CAPE ranged from 42.1 to 172 ml/min/kg (NCA) and decreased with the increasing dose of CAPE. Similarly, the volume of distribution values for CAPE ranged from 1555 to 5209 ml/kg, decreasing with increasing dose. The elimination half-life for CAPE ranged from 21.2 to 26.7 min and was independent of dose. That FCAPE was distributed extensively into rat tissues and eliminated rapidly was indicated by a high value of volume of distribution and similar short elimination half-life as that of CAPE.
Original language | American English |
---|---|
Journal | Biopharmaceutics & drug disposition |
Volume | 30 |
State | Published - Jan 1 2009 |
Keywords
- Animals
- Area Under Curve
- Caffeic Acids/administration & dosage/pharmacokinetics
- Chromatography
- Dose-Response Relationship
- Drug
- Half-Life
- High Pressure Liquid
- Injections
- Intravenous
- Male
- Nonlinear Dynamics
- Phenylethyl Alcohol/administration & dosage/analogs & derivatives/pharmacokinetics
- Rats
- Sprague-Dawley
Disciplines
- Pharmacy and Pharmaceutical Sciences