Plant-Derived Monoterpenes Suppress Hamster Kidney Cell 3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase Synthesis at the Post-Transcriptional Level

TY - JOUR

T1 - Plant-Derived Monoterpenes Suppress Hamster Kidney Cell 3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase Synthesis at the Post-Transcriptional Level

AU - Peffley, Dennis M.

AU - Gayen, Apurba K.

N1 - The rate-limiting enzyme for mevalonate and cholesterol synthesis in mammalian cells is 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) reductase. Control occurs through both transcriptional and post-transcriptional actions signaled by the end product, cholesterol, and by isoprenoid intermediates. End products of plant mevalonate metabolism, i.e., plant-derived isoprenoids, also suppress mammalian HMG-CoA reductase.

PY - 2003/1/1

Y1 - 2003/1/1

UR - https://academic.oup.com/jn/article/133/1/38/4687661

U2 - 10.1093/jn/133.1.38

DO - 10.1093/jn/133.1.38

M3 - Article

VL - 133

JO - Journal of Nutrition

JF - Journal of Nutrition

ER -