Potentiation of catecholamine inhibition of ganglionic transmission by Î”9-tetrahydrocannabinol

Frederick J. Goldstein; E. Vernot; H. K. Strahlendorf

Potentiation of catecholamine inhibition of ganglionic transmission by Î”9-tetrahydrocannabinol

Frederick J. Goldstein, E. Vernot, H. K. Strahlendorf

Department of Bio-Medical Sciences (PCOM)

Research output: Contribution to journal › Article › peer-review

Abstract

The effect of Î”9-tetrahydrocannabinol upon exogenous catecholamine inhibition of synaptic transmission was evaluated in the rabbit superior cervical ganglion. Î”9-Tetrahydrocannabinol (7.5 and 15 Î¼g/kg, i.v.) was without effect upon electrically evoked transmission, but potentiated norepinephrine-induced ganglionic inhibition. Epinephrine, but not dopamine, was similarly facilitated. Â© 1977.

Original language	American English
Journal	Neuropharmacology
Volume	16
State	Published - Jan 1 1977

Keywords

catecholamines
ganglionic transmission
Î”9-Tetrahydrocannabinol
adrenalin
dopamine
dronabinol
noradrenalin
tetrahydrocannabinol
drug potentiation
intravenous drug administration
rabbit
superior cervical ganglion
sympathetic ganglion
synaptic transmission
theoretical study
Animal
Drug Synergism
Electric Stimulation
Epinephrine
Evoked Potentials
Ganglia
Male
Norepinephrine
Rabbits
Time Factors

Disciplines

Medicine and Health Sciences

Cite this

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title = "Potentiation of catecholamine inhibition of ganglionic transmission by {\^I}”9-tetrahydrocannabinol",

abstract = " The effect of {\^I}”9-tetrahydrocannabinol upon exogenous catecholamine inhibition of synaptic transmission was evaluated in the rabbit superior cervical ganglion. {\^I}”9-Tetrahydrocannabinol (7.5 and 15 {\^I}¼g/kg, i.v.) was without effect upon electrically evoked transmission, but potentiated norepinephrine-induced ganglionic inhibition. Epinephrine, but not dopamine, was similarly facilitated. {\^A}{\textcopyright} 1977.",

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author = "Goldstein, \{Frederick J.\} and E. Vernot and Strahlendorf, \{H. K.\}",

year = "1977",

month = jan,

day = "1",

language = "American English",

volume = "16",

journal = "Neuropharmacology",

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TY - JOUR

T1 - Potentiation of catecholamine inhibition of ganglionic transmission by Î”9-tetrahydrocannabinol

AU - Goldstein, Frederick J.

AU - Vernot, E.

AU - Strahlendorf, H. K.

PY - 1977/1/1

Y1 - 1977/1/1

N2 - The effect of Î”9-tetrahydrocannabinol upon exogenous catecholamine inhibition of synaptic transmission was evaluated in the rabbit superior cervical ganglion. Î”9-Tetrahydrocannabinol (7.5 and 15 Î¼g/kg, i.v.) was without effect upon electrically evoked transmission, but potentiated norepinephrine-induced ganglionic inhibition. Epinephrine, but not dopamine, was similarly facilitated. Â© 1977.

AB - The effect of Î”9-tetrahydrocannabinol upon exogenous catecholamine inhibition of synaptic transmission was evaluated in the rabbit superior cervical ganglion. Î”9-Tetrahydrocannabinol (7.5 and 15 Î¼g/kg, i.v.) was without effect upon electrically evoked transmission, but potentiated norepinephrine-induced ganglionic inhibition. Epinephrine, but not dopamine, was similarly facilitated. Â© 1977.

KW - catecholamines

KW - ganglionic transmission

KW - Î”9-Tetrahydrocannabinol

KW - adrenalin

KW - dopamine

KW - dronabinol

KW - noradrenalin

KW - tetrahydrocannabinol

KW - drug potentiation

KW - intravenous drug administration

KW - rabbit

KW - superior cervical ganglion

KW - sympathetic ganglion

KW - synaptic transmission

KW - theoretical study

KW - Animal

KW - Drug Synergism

KW - Electric Stimulation

KW - Epinephrine

KW - Evoked Potentials

KW - Ganglia

KW - Male

KW - Norepinephrine

KW - Rabbits

KW - Time Factors

UR - https://digitalcommons.pcom.edu/scholarly_papers/1325

M3 - Article

VL - 16

JO - Neuropharmacology

JF - Neuropharmacology

ER -

Potentiation of catecholamine inhibition of ganglionic transmission by Î”9-tetrahydrocannabinol

Abstract

Keywords

Disciplines

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