PPARα agonist loaded microemulsion for oral delivery: compositions and methods of use thereof

Rudra Pangeni; M Imad Damaj; Surendra Poudel; Qingguo Xu; Adam S Duerfeldt

PPARα agonist loaded microemulsion for oral delivery: compositions and methods of use thereof

Rudra Pangeni (Inventor)
, M Imad Damaj (Inventor)
, Surendra Poudel (Inventor)
, Qingguo Xu (Inventor)
, Adam S Duerfeldt (Inventor)

Department of Pharmaceutical Sciences

Research output: Patent

Abstract

Provided herein are microemulsions that solubilize hydrophobic drugs, increasing their solubility and bioavailability. In exemplary aspects, the microemulsion comprises the peroxisome proliferator- activated receptor alpha (PPAR-α) agonist A 190 (IUPAC name 3-((4-((4-fluorobenzyl)oxy)-3-methylbenzyl)amino)benzoic acid, and methods for its use to treat pain such as chemotherapy-induced peripheral neuropathy (CIPN).

Original language	American English
Patent number	WO2026085079
State	Published - 2025

Cite this

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title = "PPARα agonist loaded microemulsion for oral delivery: compositions and methods of use thereof",

abstract = "Provided herein are microemulsions that solubilize hydrophobic drugs, increasing their solubility and bioavailability. In exemplary aspects, the microemulsion comprises the peroxisome proliferator- activated receptor alpha (PPAR-α) agonist A 190 (IUPAC name 3-((4-((4-fluorobenzyl)oxy)-3-methylbenzyl)amino)benzoic acid, and methods for its use to treat pain such as chemotherapy-induced peripheral neuropathy (CIPN).",

author = "Rudra Pangeni and Damaj, \{M Imad\} and Surendra Poudel and Qingguo Xu and Duerfeldt, \{Adam S\}",

year = "2025",

language = "American English",

type = "Patent",

note = "WO2026085079",

}

TY - PAT

T1 - PPARα agonist loaded microemulsion for oral delivery: compositions and methods of use thereof

AU - Pangeni, Rudra

AU - Damaj, M Imad

AU - Poudel, Surendra

AU - Xu, Qingguo

AU - Duerfeldt, Adam S

PY - 2025

Y1 - 2025

N2 - Provided herein are microemulsions that solubilize hydrophobic drugs, increasing their solubility and bioavailability. In exemplary aspects, the microemulsion comprises the peroxisome proliferator- activated receptor alpha (PPAR-α) agonist A 190 (IUPAC name 3-((4-((4-fluorobenzyl)oxy)-3-methylbenzyl)amino)benzoic acid, and methods for its use to treat pain such as chemotherapy-induced peripheral neuropathy (CIPN).

AB - Provided herein are microemulsions that solubilize hydrophobic drugs, increasing their solubility and bioavailability. In exemplary aspects, the microemulsion comprises the peroxisome proliferator- activated receptor alpha (PPAR-α) agonist A 190 (IUPAC name 3-((4-((4-fluorobenzyl)oxy)-3-methylbenzyl)amino)benzoic acid, and methods for its use to treat pain such as chemotherapy-induced peripheral neuropathy (CIPN).

M3 - Patent

M1 - WO2026085079

ER -