PTPRO suppresses lymph node metastasis of esophageal carcinoma by dephosphorylating MET.

Hongmei Dong; Wan Lin; Liang Du; Zhimeng Yao; Feifei Li; Shuanglong Chen; Yiteng Huang; Hongzheng Ren; Yichen Luo; Songwang Cai; Yexi Chen; Hui Tang; Xiaofu Qiu; Yunlong Pan; Xingxu Huang; Dianzheng Zhang; Shegan Gao; Sai-Ching Jim Yeung; Hao Zhang

PTPRO suppresses lymph node metastasis of esophageal carcinoma by dephosphorylating MET.

Hongmei Dong, Wan Lin, Liang Du, Zhimeng Yao, Feifei Li, Shuanglong Chen, Yiteng Huang, Hongzheng Ren, Yichen Luo, Songwang Cai, Yexi Chen, Hui Tang, Xiaofu Qiu, Yunlong Pan, Xingxu Huang, Dianzheng Zhang, Shegan Gao, Sai-Ching Jim Yeung, Hao Zhang

Department of Bio-Medical Sciences (PCOM)

Research output: Contribution to journal › Article › peer-review

Abstract

Protein tyrosine phosphatase receptor-type O (PTPRO) is a membrane-bound tyrosine phosphatase. Notably, epigenetically silenced PTPRO due to promoter hypermethylation is frequently linked to malignancies. In this study, we used cellular and animal models, and patient samples to demonstrate that PTPRO can suppress the metastasis of esophageal squamous cell carcinoma (ESCC). Mechanistically, PTPRO can inhibit MET-mediated metastasis by dephosphorylating Y1234/1235 in the kinase activation loop of MET. Patients with PTPRO ^low /p-MET ^high had significantly poor prognosis, suggesting that PTPRO ^low /p-MET ^high can serve as an independent prognostic factor for patients with ESCC.

Original language	American English
Journal	Cancer letters
Volume	567
State	Published - Jul 28 2023

Keywords

Animals
Cell Line
Esophageal Neoplasms
Esophageal Squamous Cell Carcinoma
Lymphatic Metastasis
Phosphoric Monoester Hydrolases
Prognosis
Tumor

Disciplines

Medicine and Health Sciences
Oncology

Cite this

@article{c63e5ac992bb425880cf019b09fb2caf,

title = "PTPRO suppresses lymph node metastasis of esophageal carcinoma by dephosphorylating MET.",

abstract = " Protein tyrosine phosphatase receptor-type O (PTPRO) is a membrane-bound tyrosine phosphatase. Notably, epigenetically silenced PTPRO due to promoter hypermethylation is frequently linked to malignancies. In this study, we used cellular and animal models, and patient samples to demonstrate that PTPRO can suppress the metastasis of esophageal squamous cell carcinoma (ESCC). Mechanistically, PTPRO can inhibit MET-mediated metastasis by dephosphorylating Y1234/1235 in the kinase activation loop of MET. Patients with PTPRO low /p-MET high had significantly poor prognosis, suggesting that PTPRO low /p-MET high can serve as an independent prognostic factor for patients with ESCC.",

keywords = "Animals, Cell Line, Esophageal Neoplasms, Esophageal Squamous Cell Carcinoma, Lymphatic Metastasis, Phosphoric Monoester Hydrolases, Prognosis, Tumor",

author = "Hongmei Dong and Wan Lin and Liang Du and Zhimeng Yao and Feifei Li and Shuanglong Chen and Yiteng Huang and Hongzheng Ren and Yichen Luo and Songwang Cai and Yexi Chen and Hui Tang and Xiaofu Qiu and Yunlong Pan and Xingxu Huang and Dianzheng Zhang and Shegan Gao and Yeung, {Sai-Ching Jim} and Hao Zhang",

year = "2023",

month = jul,

day = "28",

language = "American English",

volume = "567",

journal = "Cancer letters",

}

TY - JOUR

T1 - PTPRO suppresses lymph node metastasis of esophageal carcinoma by dephosphorylating MET.

AU - Dong, Hongmei

AU - Lin, Wan

AU - Du, Liang

AU - Yao, Zhimeng

AU - Li, Feifei

AU - Chen, Shuanglong

AU - Huang, Yiteng

AU - Ren, Hongzheng

AU - Luo, Yichen

AU - Cai, Songwang

AU - Chen, Yexi

AU - Tang, Hui

AU - Qiu, Xiaofu

AU - Pan, Yunlong

AU - Huang, Xingxu

AU - Zhang, Dianzheng

AU - Gao, Shegan

AU - Yeung, Sai-Ching Jim

AU - Zhang, Hao

PY - 2023/7/28

Y1 - 2023/7/28

N2 - Protein tyrosine phosphatase receptor-type O (PTPRO) is a membrane-bound tyrosine phosphatase. Notably, epigenetically silenced PTPRO due to promoter hypermethylation is frequently linked to malignancies. In this study, we used cellular and animal models, and patient samples to demonstrate that PTPRO can suppress the metastasis of esophageal squamous cell carcinoma (ESCC). Mechanistically, PTPRO can inhibit MET-mediated metastasis by dephosphorylating Y1234/1235 in the kinase activation loop of MET. Patients with PTPRO low /p-MET high had significantly poor prognosis, suggesting that PTPRO low /p-MET high can serve as an independent prognostic factor for patients with ESCC.

AB - Protein tyrosine phosphatase receptor-type O (PTPRO) is a membrane-bound tyrosine phosphatase. Notably, epigenetically silenced PTPRO due to promoter hypermethylation is frequently linked to malignancies. In this study, we used cellular and animal models, and patient samples to demonstrate that PTPRO can suppress the metastasis of esophageal squamous cell carcinoma (ESCC). Mechanistically, PTPRO can inhibit MET-mediated metastasis by dephosphorylating Y1234/1235 in the kinase activation loop of MET. Patients with PTPRO low /p-MET high had significantly poor prognosis, suggesting that PTPRO low /p-MET high can serve as an independent prognostic factor for patients with ESCC.

KW - Animals

KW - Cell Line

KW - Esophageal Neoplasms

KW - Esophageal Squamous Cell Carcinoma

KW - Lymphatic Metastasis

KW - Phosphoric Monoester Hydrolases

KW - Prognosis

KW - Tumor

UR - https://digitalcommons.pcom.edu/scholarly_papers/2209

M3 - Article

VL - 567

JO - Cancer letters

JF - Cancer letters

ER -

PTPRO suppresses lymph node metastasis of esophageal carcinoma by dephosphorylating MET.

Abstract

Keywords

Disciplines

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