RhoGDI2 suppresses bladder cancer metastasis via reduction of infammation in the tumor microenvironment

Neveen Said; Dan Theodorescu

doi:10.4161/onci.20594

RhoGDI2 suppresses bladder cancer metastasis via reduction of infammation in the tumor microenvironment

Neveen Said
, Dan Theodorescu

Research output: Contribution to journal › Article › peer-review

Abstract

Low expression of RhoGDI2 is associated with poor outcome in cancer patients. In animal models, RhoGDI2 suppresses lung metastasis by reducing the expression of the proteoglycan versican, whose levels portend poor patient prognosis. Versican promotes metastasis through enhanced tumor migration and creation of an inflammatory lung environment involving macrophages and the CCL2/CCR2 signaling axis. Targeting this mechanism may provide novel adjuvant strategies for delaying the appearance of clinical metastasis.

Original language	English
Pages (from-to)	1175-1177
Number of pages	3
Journal	OncoImmunology
Volume	1
Issue number	7
DOIs	https://doi.org/10.4161/onci.20594
State	Published - 2012
Externally published	Yes

ASJC Scopus Subject Areas

Immunology and Allergy
Immunology
Oncology

Keywords

Bladder cancer
Inflammation
Metastasis
RhoGDI2
Versican

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10.4161/onci.20594License: CC BY-NC

Cite this

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title = "RhoGDI2 suppresses bladder cancer metastasis via reduction of infammation in the tumor microenvironment",

abstract = "Low expression of RhoGDI2 is associated with poor outcome in cancer patients. In animal models, RhoGDI2 suppresses lung metastasis by reducing the expression of the proteoglycan versican, whose levels portend poor patient prognosis. Versican promotes metastasis through enhanced tumor migration and creation of an inflammatory lung environment involving macrophages and the CCL2/CCR2 signaling axis. Targeting this mechanism may provide novel adjuvant strategies for delaying the appearance of clinical metastasis.",

keywords = "Bladder cancer, Inflammation, Metastasis, RhoGDI2, Versican",

author = "Neveen Said and Dan Theodorescu",

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AU - Theodorescu, Dan

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AB - Low expression of RhoGDI2 is associated with poor outcome in cancer patients. In animal models, RhoGDI2 suppresses lung metastasis by reducing the expression of the proteoglycan versican, whose levels portend poor patient prognosis. Versican promotes metastasis through enhanced tumor migration and creation of an inflammatory lung environment involving macrophages and the CCL2/CCR2 signaling axis. Targeting this mechanism may provide novel adjuvant strategies for delaying the appearance of clinical metastasis.

KW - Bladder cancer

KW - Inflammation

KW - Metastasis

KW - RhoGDI2

KW - Versican

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DO - 10.4161/onci.20594

M3 - Article

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JO - OncoImmunology

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ER -

RhoGDI2 suppresses bladder cancer metastasis via reduction of infammation in the tumor microenvironment

Abstract

ASJC Scopus Subject Areas

Keywords

Access to Document

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