Stronger composite dental restoration results from inclusion of Extracellular Matrix Protection Factor-2 (ECPF-2), a new class of Matrix Metalloprotease 8 (MMP-8) inhibitor

Each year in the United States alone, the prevention and restorative treatment of tooth decay exceed costs of $100 billion. A considerable percentage of these costs arise from the need for retreatment and replacement of failed restorations. An innovative means of preventing the failure of dental restorations would ease the financial burden associated with retreatment procedures. Although bacterial enzymes contribute to the degradation of the layer between the composite and dentin, current research indicates a role for endogenous Matrix Metalloprotease-8 (MMP-8), a collagenase enzyme, in degradation of the hybrid layer, the region between the dentin and composite resin material.