Abstract
Objective: To investigate the expression of COX-2, PCNA and Cyclin D 1 in the progress of reflux esophagitis. Methods: A total of 54 SD rats were divided into two groups randomly model group were treated with esophagoduodenostomy; control group were normals. The lesions of esophageal mucosa were observed in the 5th, 17th, 28th, 40th week in model group and 40th week in control group, respectively. The changes of COX-2, PCNA and Cyclin D1 were evaluated by immunoperoxidase staining in the progress of reflux esophagitis. Results: The positive rates of COX-2, PCNA and Cyclin D1 were 0.0%, 0.0% and 12.5% in normal respectively, and were 42.1%, 42.1% and 42.1% in RE respectively, 73.7%, 63.2% and 63.2% in BE, and 100.0% ,100.0% and 100. 0% in EAC, respectively. The expression of COX-2, PCNA and Cyclin D1 increased gradually with the development of reflux esophagitis, and significant difference was found between RE, BE and EAC, no difference was found between BE and EAC. Conclusion: In the progress of RE, COX-2, PCNA and Cyclin D1 increased gradually.
| Original language | American English |
|---|---|
| Journal | Journal of Xi'an Jiaotong University (Medical Sciences) |
| Volume | 26 |
| State | Published - Jan 1 2005 |
Keywords
- Barrett esophagus
- COX-2
- Cyclin D1
- Esophageal adenocacinoma
- PCNA
- Reflux esophagitis
- animal experiment
- animal model
- animal tissue
- article
- controlled study
- cycline
- cyclooxygenase 2
- disease course
- disease model
- duodenostomy
- esophageal adenocarcinoma
- esophagoduodenostomy
- esophagus mucosa
- evaluation
- immunoperoxidase staining
- nonhuman
- protein expression
- randomization
- rat
- rat strain
Disciplines
- Medicine and Health Sciences