The Human Pathogen Clostridium Dificle: A Look at a Putative Involved in Protection from Oxidative Stress

Tashinea Lee; Francis E. Jenney

The Human Pathogen Clostridium Dificle: A Look at a Putative Involved in Protection from Oxidative Stress

Department of Bio-Medical Sciences (PCOM)

Research output: Contribution to conference › Presentation

Abstract

Background: Hospital acquired infections due to Clostridium difficile (C. diff) is associated with nosocomial diarrhea and pseudomembranous colitis. Using a published microarray analysis of C. diff strain 630, several open reading frames (ORFs) were noted for their upregulation under different environmental stresses. One of these genes (CD1134) is a putative glyoxalase I. The glyoxalase enzymes detoxify a side product of glycolysis, methylglyoxal, and use metals as a cofactor.

Original language	American English
State	Published - May 2 2012

Keywords

Clostridium difficile
Glyoxalase I

Disciplines

Life Sciences
Medicine and Health Sciences

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The Human Pathogen Clostridium Dificle: A Look at a Putative InvoFinal published version, 160 KBLicense: CC BY

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title = "The Human Pathogen Clostridium Dificle: A Look at a Putative Involved in Protection from Oxidative Stress",

abstract = " Background: Hospital acquired infections due to Clostridium difficile (C. diff) is associated with nosocomial diarrhea and pseudomembranous colitis. Using a published microarray analysis of C. diff strain 630, several open reading frames (ORFs) were noted for their upregulation under different environmental stresses. One of these genes (CD1134) is a putative glyoxalase I. The glyoxalase enzymes detoxify a side product of glycolysis, methylglyoxal, and use metals as a cofactor.",

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T1 - The Human Pathogen Clostridium Dificle: A Look at a Putative Involved in Protection from Oxidative Stress

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AU - Jenney, Francis E.

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Y1 - 2012/5/2

N2 - Background: Hospital acquired infections due to Clostridium difficile (C. diff) is associated with nosocomial diarrhea and pseudomembranous colitis. Using a published microarray analysis of C. diff strain 630, several open reading frames (ORFs) were noted for their upregulation under different environmental stresses. One of these genes (CD1134) is a putative glyoxalase I. The glyoxalase enzymes detoxify a side product of glycolysis, methylglyoxal, and use metals as a cofactor.

AB - Background: Hospital acquired infections due to Clostridium difficile (C. diff) is associated with nosocomial diarrhea and pseudomembranous colitis. Using a published microarray analysis of C. diff strain 630, several open reading frames (ORFs) were noted for their upregulation under different environmental stresses. One of these genes (CD1134) is a putative glyoxalase I. The glyoxalase enzymes detoxify a side product of glycolysis, methylglyoxal, and use metals as a cofactor.

KW - Clostridium difficile

KW - Glyoxalase I

UR - https://digitalcommons.pcom.edu/research_day/research_day2012/research/23

M3 - Presentation

ER -

The Human Pathogen Clostridium Dificle: A Look at a Putative Involved in Protection from Oxidative Stress

Abstract

Keywords

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