The VHL/HIF Axis in the Development and Treatment of Pheochromocytoma/Paraganglioma

Song Peng; Jun Zhang; Xintao Tan; Yiqiang Huang; Jing Xu; Natalie Silk; Dianzheng Zhang; Qiuli Liu; Jun Jiang

The VHL/HIF Axis in the Development and Treatment of Pheochromocytoma/Paraganglioma

Song Peng, Jun Zhang, Xintao Tan, Yiqiang Huang, Jing Xu, Natalie Silk, Dianzheng Zhang, Qiuli Liu, Jun Jiang

Department of Bio-Medical Sciences (PCOM)

Research output: Contribution to journal › Article › peer-review

Abstract

Pheochromocytomas and paragangliomas (PPGLs) are rare neuroendocrine tumors originating from chromaffin cells in the adrenal medulla (PCCs) or extra-adrenal sympathetic or parasympathetic paraganglia (PGLs). About 40% of PPGLs result from germline mutations and therefore they are highly inheritable. Although dysfunction of any one of a panel of more than 20 genes can lead to PPGLs, mutations in genes involved in the VHL/HIF axis including

Original language	American English
Journal	Frontiers in Endocrinology
Volume	11
State	Published - Jan 1 2020

Keywords

HIF
VHL
inhibitor
metabolism
paragangliomas
pheochromocytomas

Disciplines

Endocrinology, Diabetes, and Metabolism
Medicine and Health Sciences

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The VHL/HIF Axis in the Development and Treatment of PheochromocyFinal published version, 1.35 MBLicense: CC BY

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abstract = " Pheochromocytomas and paragangliomas (PPGLs) are rare neuroendocrine tumors originating from chromaffin cells in the adrenal medulla (PCCs) or extra-adrenal sympathetic or parasympathetic paraganglia (PGLs). About 40% of PPGLs result from germline mutations and therefore they are highly inheritable. Although dysfunction of any one of a panel of more than 20 genes can lead to PPGLs, mutations in genes involved in the VHL/HIF axis including",

keywords = "HIF, VHL, inhibitor, metabolism, paragangliomas, pheochromocytomas",

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T1 - The VHL/HIF Axis in the Development and Treatment of Pheochromocytoma/Paraganglioma

AU - Peng, Song

AU - Zhang, Jun

AU - Tan, Xintao

AU - Huang, Yiqiang

AU - Xu, Jing

AU - Silk, Natalie

AU - Zhang, Dianzheng

AU - Liu, Qiuli

AU - Jiang, Jun

PY - 2020/1/1

Y1 - 2020/1/1

N2 - Pheochromocytomas and paragangliomas (PPGLs) are rare neuroendocrine tumors originating from chromaffin cells in the adrenal medulla (PCCs) or extra-adrenal sympathetic or parasympathetic paraganglia (PGLs). About 40% of PPGLs result from germline mutations and therefore they are highly inheritable. Although dysfunction of any one of a panel of more than 20 genes can lead to PPGLs, mutations in genes involved in the VHL/HIF axis including

AB - Pheochromocytomas and paragangliomas (PPGLs) are rare neuroendocrine tumors originating from chromaffin cells in the adrenal medulla (PCCs) or extra-adrenal sympathetic or parasympathetic paraganglia (PGLs). About 40% of PPGLs result from germline mutations and therefore they are highly inheritable. Although dysfunction of any one of a panel of more than 20 genes can lead to PPGLs, mutations in genes involved in the VHL/HIF axis including

KW - HIF

KW - VHL

KW - inhibitor

KW - metabolism

KW - paragangliomas

KW - pheochromocytomas

UR - https://digitalcommons.pcom.edu/scholarly_papers/2098

M3 - Article

VL - 11

JO - Frontiers in Endocrinology

JF - Frontiers in Endocrinology

ER -

The VHL/HIF Axis in the Development and Treatment of Pheochromocytoma/Paraganglioma

Abstract

Keywords

Disciplines

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