Topical delivery of 5-fluorouracil and 6-mercaptopurine by their alkylcarbonyloxymethyl prodrugs from water: vehicle effects on design of prodrugs.

TY - JOUR

T1 - Topical delivery of 5-fluorouracil and 6-mercaptopurine by their alkylcarbonyloxymethyl prodrugs from water: vehicle effects on design of prodrugs.

AU - Sloan, Kenneth B.

AU - Wasdo, Scott

AU - Ezike-Mkparu, Udo

AU - Murray, Thomas

AU - Nickels, Donna

AU - Singh, Surjit

AU - Shanks, Thea

AU - Tovar, John

AU - Ulmer, Karen

AU - Waranis, Robert

N1 - Kenneth B. Sloan Scott Wasdo Udo Ezike-Mkparu Thomas Murray Donna Nickels Surjit Singh Thea Shanks John Tovar Karen Ulmer Robert Waranis Purpose. To determine whether the fluxes through hairless mouse skin for three homologous series of prodrugs of 5-fluorouracil (5-FU, 1) and 6-mercaptopurine (6-MP, 2) from saturated aqueous suspensions show dependencies on aqueous ( S AQ) and isopropyl myristate ( S IPM) solubilities similar to those shown by the identical compounds delivered from IPM.

PY - 2003/4/1

Y1 - 2003/4/1

UR - https://link.springer.com/article/10.1023/A:1023207118209

U2 - 10.1023/A:1023207118209

DO - 10.1023/A:1023207118209

M3 - Article

VL - 20

JO - Pharmaceutical Research

JF - Pharmaceutical Research

ER -