Transcription factor cascades in congenital heart malformation

Cathy J. Hatcher; Nata Diman; Deborah A. McDermott; Craig T. Basson

Transcription factor cascades in congenital heart malformation

Cathy J. Hatcher, Nata Diman, Deborah A. McDermott, Craig T. Basson

Department of Bio-Medical Sciences (PCOM)

Research output: Contribution to journal › Article › peer-review

Abstract

New observations reveal that GATA-4 mutations are one underlying cause of human cardiac septal defects. Recent data has shed light on a potential multiprotein complex formed by GATA-4, TBX5 and NKX2.5, which might act synergistically to transcriptionally regulate other cardiac specific genes. The addition of GATA-4 to the list of genes involved in human congenital heart malformation prompts consideration of how modern molecular genetic advances should be applied to clinical care.

Original language	American English
Journal	Trends in molecular medicine
Volume	9
State	Published - Jan 1 2003

Disciplines

Developmental Biology

Cite this

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title = "Transcription factor cascades in congenital heart malformation",

abstract = " New observations reveal that GATA-4 mutations are one underlying cause of human cardiac septal defects. Recent data has shed light on a potential multiprotein complex formed by GATA-4, TBX5 and NKX2.5, which might act synergistically to transcriptionally regulate other cardiac specific genes. The addition of GATA-4 to the list of genes involved in human congenital heart malformation prompts consideration of how modern molecular genetic advances should be applied to clinical care.",

author = "Hatcher, {Cathy J.} and Nata Diman and McDermott, {Deborah A.} and Basson, {Craig T.}",

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journal = "Trends in molecular medicine",

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T1 - Transcription factor cascades in congenital heart malformation

AU - Hatcher, Cathy J.

AU - Diman, Nata

AU - McDermott, Deborah A.

AU - Basson, Craig T.

PY - 2003/1/1

Y1 - 2003/1/1

N2 - New observations reveal that GATA-4 mutations are one underlying cause of human cardiac septal defects. Recent data has shed light on a potential multiprotein complex formed by GATA-4, TBX5 and NKX2.5, which might act synergistically to transcriptionally regulate other cardiac specific genes. The addition of GATA-4 to the list of genes involved in human congenital heart malformation prompts consideration of how modern molecular genetic advances should be applied to clinical care.

AB - New observations reveal that GATA-4 mutations are one underlying cause of human cardiac septal defects. Recent data has shed light on a potential multiprotein complex formed by GATA-4, TBX5 and NKX2.5, which might act synergistically to transcriptionally regulate other cardiac specific genes. The addition of GATA-4 to the list of genes involved in human congenital heart malformation prompts consideration of how modern molecular genetic advances should be applied to clinical care.

UR - https://digitalcommons.pcom.edu/scholarly_papers/512

M3 - Article

VL - 9

JO - Trends in molecular medicine

JF - Trends in molecular medicine

ER -

Transcription factor cascades in congenital heart malformation

Abstract

Disciplines

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