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VEGF expression in forestomach cancer and precancerous lesions in mice and investigation of chemoprophylaxis trail

Qian Chen, X. Lian, W. Zheng, B. Zhou, X. Wu

Research output: Contribution to journalArticlepeer-review

Abstract

Objective: To investigate intervention and mechanism of forestomach cancer and precancerous lesions in mice by Chanpi, Quanchong and Fengfang mixed liquid (CQF liquid). Methods: The model of forestomach cancer and precancerous lesions in mice was established by N-nitrososarcosine ethyl ester and sodium nitrite perfusing stomach; VEGF expressions in cancer-induced group (32 cases), the traditional Chinese medicine (20 cases) and blocked group (48 cases) were determined by ELPS. Results: Circled digit one The incidence of cancer and precancerous lesions was markedly higher in cancer-induced group than in blocked group; Circled digit two the positive rate and intensity of VEGF expression were significantly higher in cancer-induced group than in blocked group. Conclusion: CQF liquid can interrupt forestomach cancer and precancerous lesions in mice, and is related to VEGF expression. VEGF is a factor involved in forestomach cancer and precancerous lesions in mice.

Original languageAmerican English
JournalJournal of Xi'an Jiaotong University (Medical Sciences)
Volume24
StatePublished - Jan 1 2003

Keywords

  • Chemoprophylaxis
  • Forestomach cancer
  • Immunohistochemistry
  • VEGF

Disciplines

  • Medicine and Health Sciences

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